Sarcopenia negatively affects hip structure analysis variables in a group of Lebanese postmenopausal women

Hayman Saddik (1, 2) , Riad Nasr (1, 3) , Antonio Pinti (2, 3) , Eric Watelain (4) , Ibrahim Fayad (1) , Rafic Baddoura (5) , Abdel Jalil Berro (1, 6) , Nathalie Al Rassy (7) , Eric Lespessailles (2) , Hechmi Toumi (2) , Rawad El Hage (1)

1 UOB - University of Balamand [Liban]
2 I3MTO - Imagerie Multimodale Multiéchelle et Modélisation du Tissu Osseux et articulaire
3 DeVisu - Laboratoire en Design Visuel et Urbain - EA 2445
4 IAPS - Impact de l'Activité Physique sur la Santé
5 USJ - Université Saint-Joseph de Beyrouth
6 APERE - Adaptations Physiologiques à l'Exercice et Réadaptation à l'effort - UR UPJV 3300
7 MABLab (ex-pmoi) - Marrow Adiposity & Bone Lab - Adiposité Médullaire et Os - ULR 4490

Background The current study’s purpose is to compare hip structural analysis variables in a group of postmenopausal women with sarcopenia and another group of postmenopausal women with normal skeletal muscle mass index. To do so, the current study included 8 postmenopausal women (whose ages ranged between 65 and 84 years) with sarcopenia and 60 age-matched controls (with normal skeletal muscle mass index (SMI)). Body composition and bone parameters were evaluated by dual-energy X-ray absorptiometry (DXA). Results Weight, lean mass, body mass index, femoral neck cross-sectional area (FN CSA), FN section modulus (Z), FN cross sectional moment of inertia (CSMI), intertrochanteric (IT) CSA, IT Z, IT CSMI, IT cortical thickness (CT), femoral shaft (FS) CSA, FS Z and FS CSMI were significantly greater ( p < 0.05) in women with normal SMI compared to women with sarcopenia. In the whole population, SMI was positively associated with IT CSA, IT Z, IT CSMI, IT CT, FS CSA, FS Z, FS CSMI, FS CT but negatively correlated to IT buckling ratio (BR) and FS BR. Conclusion The current study suggests that sarcopenia has a negative effect on hip bone strength indices in postmenopausal women.

Mots clés: Sarcopenia; DXA imaging; Bone strength indices; Fracture risk; Menopause; Sarcopenia; Sarcopenia; Sarcopenia

Domaines: Rhumatologie et système ostéo-articulaire

Hayman Saddik, Riad Nasr, Antonio Pinti, Eric Watelain, Ibrahim Fayad, et al.. Sarcopenia negatively affects hip structure analysis variables in a group of Lebanese postmenopausal women. BMC Bioinformatics, 2020, 21 (Supplément 2), ⟨10.1186/s12859-020-3353-9⟩. ⟨hal-03244814⟩