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Article Dans Une Revue Parkinsonism & Related Disorders Année : 2022

Personality Assessment with Temperament and Character Inventory in Parkinson's Disease.

1 ToNIC - Toulouse NeuroImaging Center
2 CHU Toulouse - Centre Hospitalier Universitaire de Toulouse
3 CH Brive - Centre Hospitalier de Brive-la-Gaillarde
4 CRNL - Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center
5 UCBL - Université Claude Bernard Lyon 1
6 Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL]
7 HCL - Hospices Civils de Lyon
8 CHU Marseille
9 CHU Pitié-Salpêtrière [AP-HP]
10 SU FM - Sorbonne Université - Faculté de Médecine
11 ICM - Institut du Cerveau = Paris Brain Institute
12 Hôpital de la Fondation Ophtalmologique Adolphe de Rothschild [AP-HP]
13 NeuroToul - Centre d’Excellence en Maladies Neurodégénératives
14 CIC - Biotherapie - Toulouse
15 LilNCog - Lille Neurosciences & Cognition - U 1172
16 CHRU Lille - Centre Hospitalier Régional Universitaire [CHU Lille]
17 NEUROSPIN - Service NEUROSPIN
18 Hôpital Foch [Suresnes]
19 UNICOG-U992 - Neuroimagerie cognitive - Psychologie cognitive expérimentale
20 DC2N - Différenciation et communication neuronale et neuroendocrine
21 CHU Rouen
22 CIC - Centre d'Investigation Clinique [Rennes]
23 Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Ponchaillou]
24 INP Clermont Auvergne - Institut national polytechnique Clermont Auvergne
25 IP - Institut Pascal
26 CHU Bordeaux
27 HUS - Les Hôpitaux Universitaires de Strasbourg
28 FMTS - Fédération de Médecine Translationnelle de Strasbourg
29 IGBMC - Institut de Génétique et de Biologie Moléculaire et Cellulaire
30 CHRU Nancy - Centre Hospitalier Régional Universitaire de Nancy
31 CHU Nice - Centre Hospitalier Universitaire de Nice
32 CHU Amiens-Picardie
33 LNFP - Laboratoire de Neurosciences Fonctionnelles et Pathologies - UR UPJV 4559
34 CHU Nantes - Centre Hospitalier Universitaire de Nantes
Alexandre Eusebio
  • Fonction : Auteur
Caroline Moreau
Nicolas Auzou
  • Fonction : Auteur
David Devos

Résumé

INTRODUCTION: There is a growing interest in personality evaluation in Parkinson's disease (PD), following observations of specific temperaments in PD patients. Therefore, our objective was to evaluate personality dimensions from the Temperament and Character Inventory (TCI) in a cohort of fluctuating PD patients considered for deep brain stimulation. METHODS: Fluctuating PD patients from the PREDISTIM cohort were included. Description of TCI dimensions and comparison with a French normative cohort were performed. Pearson correlations between TCI dimensions and motor, behavioral and cognitive variables were investigated. Structural and internal consistency analysis of the TCI were further assessed. RESULTS: The 570 PD patients presented significant higher scores in Harm Avoidance, Reward Dependence, Persistence, Self-Directedness and Cooperativeness and significant lower scores in Self-Transcendence compared to the French normative cohort; only Novelty Seeking scores were not different. Harm Avoidance and Self-directedness scores were correlated with PDQ-39 total, HAMD, HAMA scores, and anxiolytic/antidepressant treatment. Novelty Seeking scores were correlated with impulsivity. Pearson correlations between TCI dimensions, principal component analysis of TCI sub-dimensions and Cronbach's alpha coefficients showed adequate psychometric proprieties. CONCLUSION: The TCI seems to be an adequate tool to evaluate personality dimensions in PD with good structural and internal consistencies. These fluctuating PD patients also have specific personality dimensions compared to normative French population. Moreover, Harm Avoidance and Self-Directedness scores are associated with anxio-depressive state or quality of life and, and Novelty Seeking scores with impulsivity.
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hal-03767971 , version 1 (02-05-2023)

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Mathilde Boussac, Christophe Arbus, Olivier Colin, Chloé Laurencin, Alexandre Eusebio, et al.. Personality Assessment with Temperament and Character Inventory in Parkinson's Disease.. Parkinsonism & Related Disorders, 2022, 103, pp.34--41. ⟨10.1016/j.parkreldis.2022.08.004⟩. ⟨hal-03767971⟩
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