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Nanoarchitectonics of Electrically Activable Phosphonium Self-Assembled Monolayers to Efficiently Kill and Tackle Bacterial Infections on Demand

Abstract : Prosthetic implants are widely used in dentistry and orthopedics and, as a result, infections can occur which cause their removal. Therefore, it is essential to propose methods of eradicating the bacteria that remain on the prosthesis during treatment. For this purpose, it is necessary to develop surfaces whose antibacterial activity can be controlled. Herein, we designed innovative and smart phosphonium self-assembled monolayer (SAM) interfaces that can be electrically activated on demand for controlling bacterial contaminations on solid surfaces. Upon electroactivation with a low potential (0.2 V for 60 min., conditions determined through a DOE), a successful stamping out of Gram-positive and Gram-negative bacterial strains was obtained with SAM-modified titanium surfaces, effectively killing 95% of Staphylococcus aureus and 90% Klebsiellapneumoniae. More importantly, no toxicity towards eukaryotic cells was observed which further enhances the biocompatible character of these novel surfaces for further implementation.
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https://hal.archives-ouvertes.fr/hal-03702295
Contributor : Jean-Manuel Raimundo Connect in order to contact the contributor
Submitted on : Thursday, June 30, 2022 - 2:48:51 PM
Last modification on : Saturday, July 2, 2022 - 3:04:09 AM

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10.3390:ijms23042183.pdf
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Distributed under a Creative Commons Attribution 4.0 International License

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Serena Carrara, Florent Rouvier, Sanjana Auditto, Frédéric Brunel, Charlotte Jeanneau, et al.. Nanoarchitectonics of Electrically Activable Phosphonium Self-Assembled Monolayers to Efficiently Kill and Tackle Bacterial Infections on Demand. International Journal of Molecular Sciences, MDPI, 2022, 23 (4), pp.2183. ⟨10.3390/ijms23042183⟩. ⟨hal-03702295⟩

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