Impact of Endocrine Disruptors upon Non-Genetic Inheritance - Périnatalité et Risques Toxiques - UMR INERIS_I 1 Accéder directement au contenu
Article Dans Une Revue International Journal of Molecular Sciences Année : 2022

Impact of Endocrine Disruptors upon Non-Genetic Inheritance

Résumé

Similar to environmental factors, EDCs (endocrine-disrupting chemicals) can influence gene expression without modifying the DNA sequence. It is commonly accepted that the transgenerational inheritance of parentally acquired traits is conveyed by epigenetic alterations also known as ``epimutations''. DNA methylation, acetylation, histone modification, RNA-mediated effects and extracellular vesicle effects are the mechanisms that have been described so far to be responsible for these epimutations. They may lead to the transgenerational inheritance of diverse phenotypes in the progeny when they occur in the germ cells of an affected individual. While EDC-induced health effects have dramatically increased over the past decade, limited effects on sperm epigenetics have been described. However, there has been a gain of interest in this issue in recent years. The gametes (sperm and oocyte) represent targets for EDCs and thus a route for environmentally induced changes over several generations. This review aims at providing an overview of the epigenetic mechanisms that might be implicated in this transgenerational inheritance.
Fichier principal
Vignette du fichier
ijms-23-03350-v2.pdf (1.03 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-03641413 , version 1 (06-05-2022)

Identifiants

Citer

Debbie Montjean, Anne-Sophie Neyroud, Marina G. Yefimova, Moncef Ben Khalifa, Rosalie Cabry, et al.. Impact of Endocrine Disruptors upon Non-Genetic Inheritance. International Journal of Molecular Sciences, 2022, 23 (6), ⟨10.3390/ijms23063350⟩. ⟨hal-03641413⟩
81 Consultations
61 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More