Low-Valent Calix[4]arene Glycoconjugates Based on Hydroxamic Acid Bearing Linkers as Potent Inhibitors in a Model of Ebola Virus Cis-Infection and HCMV-gB-Recombinant Glycoprotein Interaction with MDDC Cells by Blocking DC-SIGN

Khouloud Chakroun (1) , Marwa Taouai (1) , Vanessa Porkolab (2) , Joanna Luczkowiak (3) , Roman Sommer , Coraline Cheneau (4) , David Mathiron (5) , Mohamed Amine Ben Maaouia (1) , Serge Pilard (6) , Rym Abidi (7) , Catherine Mullié (8) , Franck Fieschi (2) , Peter Cragg (9) , Franck Halary (10) , Rafael Delgado (11) , Mohammed Benazza (1)

1 LG2A - Laboratoire de Glycochimie, des Antimicrobiens et des Agro-ressources - UMR CNRS 7378
2 IBS - UMR 5075 - Institut de biologie structurale
3 Instituto de Investigación Hospital Universitario 12 de Octubre
4 U1064 Inserm - CRTI - Centre de Recherche en Transplantation et Immunologie
5 PFA - Plateforme Analytique - UPJV
6 UPJV - Université de Picardie Jules Verne
7 Laboratoire d'Application de la Chimie aux Ressources et Substances Naturelles de l'Environnement
8 AGIR - Agents infectieux, résistance et chimiothérapie - UR UPJV 4294
9 School of Pharmacy & Biomolecular Sciences, University of Brighton, Brighton BN2 4GJ, U.K
10 ITUN - Institut de transplantation urologie-néphrologie
11 Instituto de Investigación Hospital Universitario 12 de Octubre

Domaines: Chimie

Khouloud Chakroun, Marwa Taouai, Vanessa Porkolab, Joanna Luczkowiak, Roman Sommer, et al.. Low-Valent Calix[4]arene Glycoconjugates Based on Hydroxamic Acid Bearing Linkers as Potent Inhibitors in a Model of Ebola Virus Cis-Infection and HCMV-gB-Recombinant Glycoprotein Interaction with MDDC Cells by Blocking DC-SIGN. Journal of Medicinal Chemistry, 2021, 64 (19), pp.14332-14343. ⟨10.1021/acs.jmedchem.1c00818⟩. ⟨hal-03539608⟩