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Article dans une revue

The impact of endocrine disruptor chemicals on oocyte/embryo and clinical outcomes in IVF

Abstract : The negative impact of endocrine-disrupting pesticides on human fertility is now a key issue in reproductive health. There are much fewer literature data about the impact of pesticide exposure on women than on men and very few studies of women participating in an in vitro fertilization (IVF) programme. In the present review, we found that (1) various pesticides with an endocrine-disrupting action are associated with poor oocyte maturation and competency, embryonic defects and poor IVF outcomes, and (2) some pesticide compounds are linked to specific causes of female infertility, such as premature ovarian insufficiency, polycystic ovarian syndrome, and endometriosis. IVF participants living in agricultural regions should be informed about the fertility decline, low ongoing pregnancy rates, and elevated risk of miscarriage associated with exposure to high doses of pesticides.
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Contributeur : Louise Dessaivre Connectez-vous pour contacter le contributeur
Soumis le : jeudi 27 janvier 2022 - 09:43:25
Dernière modification le : jeudi 31 mars 2022 - 11:00:02

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Rosalie Cabry, Philippe Merviel, Aicha Madkour, Elodie Lefranc, Florence Scheffler, et al.. The impact of endocrine disruptor chemicals on oocyte/embryo and clinical outcomes in IVF. ENDOCRINE CONNECTIONS, 2020, 9 (6), pp.R134-R142. ⟨10.1530/EC-20-0135⟩. ⟨hal-03545113⟩



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