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Characteristics and outcomes ofCOVID-19 in hospitalized patients with and without diabetes

Abstract : Background Coronavirus disease 2019 (COVID-19) is a rapidly progressing pandemic, with four million confirmed cases and 280 000 deaths at the time of writing. Some studies have suggested that diabetes is associated with a greater risk of developing severe forms of COVID-19. The primary objective of the present study was to compare the clinical features and outcomes in hospitalized COVID-19 patients with vs without diabetes. Methods All consecutive adult patients admitted to Amiens University Hospital (Amiens, France) with confirmed COVID-19 up until April 21st, 2020, were included. The composite primary endpoint comprised admission to the intensive care unit (ICU) and death. Both components were also analysed separately in a logistic regression analysis and a Cox proportional hazards model. Results A total of 433 patients (median age: 72; 238 (55%) men; diabetes: 115 (26.6%)) were included. Most of the deaths occurred in non-ICU units and among older adults. Multivariate analyses showed that diabetes was associated neither with the primary endpoint (odds ratio (OR): 1.12; 95% confidence interval (CI): 0.66-1.90) nor with mortality (hazard ratio: 0.73; 95%CI: 0.40-1.34) but was associated with ICU admission (OR: 2.06; 95%CI 1.09-3.92,P= .027) and a longer length of hospital stay. Age was negatively associated with ICU admission and positively associated with death. Conclusions Diabetes was prevalent in a quarter of the patients hospitalized with COVID-19; it was associated with a greater risk of ICU admission but not with a significant elevation in mortality. Further investigation of the relationship between COVID-19 severity and diabetes is warranted.
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https://hal-u-picardie.archives-ouvertes.fr/hal-03547675
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Soumis le : vendredi 28 janvier 2022 - 17:08:19
Dernière modification le : lundi 29 août 2022 - 11:28:25

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Abdallah Al-Salameh, Jean-Philippe Lanoix, Youssef Bennis, Claire Andrejak, Etienne Brochot, et al.. Characteristics and outcomes ofCOVID-19 in hospitalized patients with and without diabetes. Diabetes/Metabolism Research and Reviews, Wiley, 2021, 37 (3), ⟨10.1002/dmrr.3388⟩. ⟨hal-03547675⟩

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