Neurodevelopmental Outcomes after Premedication with Atropine/Propofol vs Atropine/Atracurium/Sufentanil for Neonatal Intubation: 2-Year Follow-Up of a Randomized Clinical Trial

Manon Tauzin (1, 2) , Laetitia Marchand-Martin (3) , Cecile Lebeaux (4) , Sophie Breinig (5, 6) , Olivier Claris (7) , Pierre Tourneux (8) , Ceneric Alexandre (9) , Corinne Levy (10) , Camille Jung (11) , Agnes Dechartres (12) , Xavier Durrmeyer (13) , Premedication Trial Tracheal Intub

1 Hôpital Henri Mondor
2 Département de Pharmacologie Clinique [CHU Cochin]
3 CRESS - U1153 - Equipe 1 : EPOPé - Épidémiologie Obstétricale, Périnatale et Pédiatrique
4 CHU Trousseau [APHP]
5 CHU Toulouse - Centre Hospitalier Universitaire de Toulouse
6 CERPOP - Centre d'Epidémiologie et de Recherche en santé des POPulations
7 HCL - Hospices Civils de Lyon
8 PERITOX - Périnatalité et Risques Toxiques - UMR INERIS_I 1
9 CHU Caen
10 ACTIV - Association Clinique et Thérapeutique Infantile du Val de Marne
11 Centre de Recherche Clinique - Centre de Ressource Biologique [CHI Créteil]
12 CHU Charles Foix [AP-HP]
13 CHIC - Centre Hospitalier Intercommunal de Créteil

This study followed 173 newborn infants in the PREmedication Trial for Tracheal Intubation of the NEOnate multicenter, double-blind, randomized controlled trial of atropine-propofol vs atropine-atracurium-sufentanil for premedication before nonemergency intubation. At 2 years of corrected age, there was no significant difference between the groups in death or risk of neurodevelopmental delay assessed with the Ages and Stages Questionnaire.

Domaines: Sciences du Vivant [q-bio]

Manon Tauzin, Laetitia Marchand-Martin, Cecile Lebeaux, Sophie Breinig, Olivier Claris, et al.. Neurodevelopmental Outcomes after Premedication with Atropine/Propofol vs Atropine/Atracurium/Sufentanil for Neonatal Intubation: 2-Year Follow-Up of a Randomized Clinical Trial. The Journal of Pediatrics, 2021, 231, pp.273+. ⟨10.1016/j.jpeds.2020.12.001⟩. ⟨hal-03548014⟩