Epstein-Barr Virus-related mucocutaneous ulcer lymphoma associated with Crohn's disease, treated with monoclonal antibody anti-CD30

Lydia Montes , Estelle Tredez (1) , Clara Yzet (2) , Caroline Delette (2) , Denis Chatelain (2) , Delphine Lebon (2) , Mathurin Fumery (2, 3) , Jean-Pierre Marolleau (4)

1 UPJV - Université de Picardie Jules Verne
2 CHU Amiens-Picardie
3 PERITOX - Périnatalité et Risques Toxiques - UMR INERIS_I 1
4 Laboratoire d'Hématologie [CHU Amiens]

Epstein-Barr virus-related mucocutaneous ulcer lymphoma is a rare entity promoted by immunosuppression. It is less described in inflammatory bowel diseases, and mostly these are refractory diseases. CD30 acts to Epstein-Barr virus (EBV) local proliferation and thus could be an interesting target. Brentuximab vedotin could become a new helpful tool.

Mots clés: brentuximab vedotin; CD30; epstein-barr virus; immunosuppression; lymphoma

Domaines: Sciences du Vivant [q-bio]

Lydia Montes, Estelle Tredez, Clara Yzet, Caroline Delette, Denis Chatelain, et al.. Epstein-Barr Virus-related mucocutaneous ulcer lymphoma associated with Crohn's disease, treated with monoclonal antibody anti-CD30. Clinical Case Reports, 2020, 8 (6), pp.958-961. ⟨10.1002/ccr3.2721⟩. ⟨hal-03551528⟩