Disease course of inflammatory bowel disease unclassified in a European population-based inception cohort: An Epi-IBD study - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of Gastroenterology and Hepatology Année : 2019

Disease course of inflammatory bowel disease unclassified in a European population-based inception cohort: An Epi-IBD study

(1) , (2) , (2) , (3) , (4) , (4, 5) , (6) , (6, 7, 8) , , (9, 10) , (10, 11, 12) , (13) , (14) , (15) , (16) , (16) , (17, 18) , (17, 18) , (19) , (19, 20) , (21) , (21) , (22) , (22) , (23) , , (24) , (25) , (25) , (26) , (26) , (27) , (27) , (28) , (28) , (29) , (29) , (30) , (30) , (31) , , (32) , (33) , (33, 34) , (1) , (1)
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
Pierre Ellul
Dana Duricova
  • Fonction : Auteur
Ioannis P. Kaimakliotis
  • Fonction : Auteur
Mathurin Fumery
Carl Eriksson
  • Fonction : Auteur
Natalia Pedersen
  • Fonction : Auteur
Amalia Carmona
  • Fonction : Auteur

Résumé

Background and Aim A definitive diagnosis of Crohn's disease (CD) or ulcerative colitis (UC) is not always possible, and a proportion of patients will be diagnosed as inflammatory bowel disease unclassified (IBDU). The aim of the study was to investigate the prognosis of patients initially diagnosed with IBDU and the disease course during the following 5 years. Methods The Epi-IBD study is a prospective population-based cohort of 1289 IBD patients diagnosed in centers across Europe. Clinical data were captured prospectively throughout the follow-up period. Results Overall, 476 (37%) patients were initially diagnosed with CD, 701 (54%) with UC, and 112 (9%) with IBDU. During follow-up, 28 (25%) IBDU patients were changed diagnoses to either UC (n = 20, 71%) or CD (n = 8, 29%) after a median of 6 months (interquartile range: 4-12), while 84 (7% of the total cohort) remained IBDU. A total of 17 (15%) IBDU patients were hospitalized for their IBD during follow-up, while 8 (7%) patients underwent surgery. Most surgeries (n = 6, 75%) were performed on patients whose diagnosis was later changed to UC; three of these colectomies led to a definitive diagnosis of UC. Most patients (n = 107, 96%) received 5-aminosalicylic acid, while 11 (10%) patients received biologicals, of whom five remained classified as IBDU. Conclusions In a population-based inception cohort, 7% of IBD patients were not given a definitive diagnosis of IBD after 5 years of follow-up. One in four patients with IBDU eventually was classified as CD or UC. Overall, the disease course and medication burden in IBDU patients were mild.

Dates et versions

hal-03552292 , version 1 (02-02-2022)

Identifiants

Citer

Johan Burisch, Stefania Chetcuti Zammit, Pierre Ellul, Svetlana Turcan, Dana Duricova, et al.. Disease course of inflammatory bowel disease unclassified in a European population-based inception cohort: An Epi-IBD study. Journal of Gastroenterology and Hepatology, 2019, 34 (6), pp.996-1003. ⟨10.1111/jgh.14563⟩. ⟨hal-03552292⟩
16 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook Twitter LinkedIn More