Accéder directement au contenu Accéder directement à la navigation
Article dans une revue

Lessons from a large nationwide cohort of 350 children with ovarian mature teratoma: A study in favor of ovarian-sparing surgery

Fanny Delehaye Sabine Sarnacki 1, 2 Daniel Orbach 3 Alaa Cheikhelard Jeremie Rouger Jean-Jacques Parienti 4, 5 Cecile Faure-Conter 6 Frederic Hameury 7 Frederique Dijoud 8, 7 Estelle Aubry 9 Agnes Wacrenier 10 Edouard Habonimana 11 Camille Duchesne Solene Joseph Hortense Alliot 12 Aurelien Scalabre 13 Yann Chaussy 14 Guillaume Podevin 15 Anne Croue 16 Elodie Haraux 17, 18 Marie Pierre Guibal Isabelle Pommepuy 19 Quentin Ballouhey 20 Frederic Lavrand 21 Matthieu Peycelon 22, 23, 24, 25, 26, 27, 28 Sabine Irtan 29 Florent Guerin 30 Anne Dariel 31 Claude Borionne Louise Galmiche 32 Julien Rod 33, 34 
12 CRCINA-ÉQUIPE 4 - Immunogenic Cell Death and Mesothelioma Therapy
CRCINA - Centre de Recherche en Cancérologie et Immunologie Nantes-Angers
Abstract : Background Ovarian mature teratoma (OMT) is a common ovarian tumor found in the pediatric population. In 10%-20% of cases, OMT occurs as multiple synchronous or metachronous lesions on ipsi- or contralateral ovaries. Ovarian-sparing surgery (OSS) is recommended to preserve fertility, but total oophorectomy (TO) is still performed. Design This study reviews the clinical data of patients with OMT, and analyzes risk factors for second events. A national retrospective review of girls under 18 years of age with OMTs was performed. Data on clinical features, imaging, laboratory studies, surgical reports, second events and their management were retrieved. Results Overall, 350 children were included. Eighteen patients (5%) presented with a synchronous bilateral form at diagnosis. Surgery was performed by laparotomy (85%) and laparoscopy (15%). OSS and TO were performed in 59% and 41% of cases, respectively. Perioperative tumor rupture occurred in 23 cases, independently of the surgical approach. Twenty-nine second events occurred (8.3%) in a median time of 30.5 months from diagnosis (ipsilateral: eight cases including one malignant tumor; contralateral: 18 cases; both ovaries: three cases). A large palpable mass, bilateral forms, at diagnosis and perioperative rupture had a statistical impact on the risk of second event, whereas the type of surgery or approach did not. Conclusion This study is a plea in favor of OSS as the first-choice treatment of OMT when possible. Close follow-up during the first 5 years is mandatory considering the risk of 8.3% of second events, especially in cases with risk factors.
Type de document :
Article dans une revue
Liste complète des métadonnées
Contributeur : Louise DESSAIVRE Connectez-vous pour contacter le contributeur
Soumis le : mercredi 2 février 2022 - 19:50:46
Dernière modification le : mardi 30 août 2022 - 11:20:27



Fanny Delehaye, Sabine Sarnacki, Daniel Orbach, Alaa Cheikhelard, Jeremie Rouger, et al.. Lessons from a large nationwide cohort of 350 children with ovarian mature teratoma: A study in favor of ovarian-sparing surgery. Pediatric Blood and Cancer, Wiley, 2022, 69 (3), ⟨10.1002/pbc.29421⟩. ⟨hal-03553542⟩



Consultations de la notice