Management of an outbreak of invasive Kingella kingae skeletal infections in a day care center

Céline Klein (1, 2) , F. Peltier , E. Pluquet , Elodie Haraux (1, 3) , Richard Gouron (1) , Cédric Joseph (4, 5)

1 CHU Amiens-Picardie
2 MP3CV - Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517
3 PERITOX - Périnatalité et Risques Toxiques - UMR INERIS_I 1
4 UPJV - Université de Picardie Jules Verne
5 AGIR - Agents infectieux, résistance et chimiothérapie - UR UPJV 4294

Background: Kingella kingae (Kk) is frequently responsible for invasive skeletal infections in children aged 3-36 months. However, few outbreaks of invasive Kk infections in day care centers have been reported. The objective of the present study was to describe (a) the clinical and laboratory data recorded during an outbreak of invasive Kk skeletal infections, and (b) the management of the outbreak. Method: Four children from the same day care center were included in the study May and June 2019. We retrospectively analyzed the children's clinical presentation and their radiological and laboratory data. We also identified all the disease control measures taken in the day care center. Results: We observed cases of septic arthritis of the wrist (case #1), shoulder arthritis (case #2), knee arthritis (case #3) ans cervical spondylodiscitis (case #4). All cases presented with an oropharyngeal infection and concomitant fever prior to diagnosis of the skeletal infection. All cases were misdiagnosed at the initial presentation. The mean (range) age at diagnosis was 10.75 months (9-12). The three patients with arthritis received surgical treatment. All patients received intravenous and then oral antibiotics. In cases 1 and 2, Kk was detected using real-time PCR and a ST25-rtxA1 clone was identified. The outcome was good in all four cases. Four other children in the day care center presented with scabies during this period and were treated with systemic ivermectin. The Regional Health Agency was informed, and all the parents of children attending the day care center received an information letter. The day care center was cleaned extensively. Conclusion: Our results highlight the variety of features of invasive skeletal Kk infections in children and (given the high risk of transmission in day care centers) the importance of diagnosing cases as soon as possible. (C) 2020 French Society of Pediatrics. Published by Elsevier Masson SAS. All rights reserved.

Mots clés: Septic arthritis; Kingella kingae; Spondylodiscitis; Outbreak; Day care center

Domaines: Sciences du Vivant [q-bio]

Céline Klein, F. Peltier, E. Pluquet, Elodie Haraux, Richard Gouron, et al.. Management of an outbreak of invasive Kingella kingae skeletal infections in a day care center. Archives de Pédiatrie, 2021, 28 (1), pp.12-15. ⟨10.1016/j.arcped.2020.11.005⟩. ⟨hal-03553547⟩