Metformin alleviates stroke severity in female mice with chronic kidney disease through AMPK activation and subsequent decrease of microglia/macrophages M1 polarization

Maria Grissi (1) , Cedric Boudot (1) , Maryam Assem (1, 2) , Sabrina Poirot-Leclercq (1) , Gaëlle Lenglet (1) , Mathilde Lando (1, 2) , Carine Avondo (1) , Agnes Boullier (1) , Jean-Daniel Lalau (2, 3, 1) , Gabriel Choukroun (2, 1) , Ziad Massy (4, 5) , Saïd Kamel (1) , Jean-Marc Chillon (6) , Lucie Henaut (1)

1 MP3CV - Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517
2 CHU Amiens-Picardie
3 PERITOX - Périnatalité et Risques Toxiques - UMR INERIS_I 1
4 Service Néphrologie/Dialyse [AP-HP Ambroise-Paré]
5 CESP - Centre de recherche en épidémiologie et santé des populations
6 Affectations Mineralisantes du Systeme Cardiovasculaire : Calcifications Arterielles et Valvulaires Aortiques

Domaines: Sciences du Vivant [q-bio]

Maria Grissi, Cedric Boudot, Maryam Assem, Sabrina Poirot-Leclercq, Gaëlle Lenglet, et al.. Metformin alleviates stroke severity in female mice with chronic kidney disease through AMPK activation and subsequent decrease of microglia/macrophages M1 polarization. Nephrology Dialysis Transplantation, 2019, 34 (1), pp.36. ⟨hal-03555479⟩