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Usefulness of (1,3) beta-D-glucan detection in bronchoalveolar lavage samples in Pneumocystis pneumonia and Pneumocystis pulmonary colonization

Abstract : Objective of the study. - Recent data demonstrate the usefulness of (1,3) beta-D-glucan (BG) Bronchoalveolar lavage detection in serum samples to distinguish patients developing Pneumocystis pneumonia and samples; patients who are colonized by the fungus. In contrast, data of BG detection in bronchoalveolar Pneumocystis lavage (BAL) samples from these patient populations are still rare. pneumonia; Patients. - In this context, we determined BG levels in BAL samples from 11 Pneumocystis Pneumocystis pneumonia (PCP) patients, 10 colonized patients, and 24 Pneumocystis-uninfected patients. Materials and methods. - BG levels were determined on each BAL sample using the Fungitell (R) kit (Associates of Cape Cod, Inc., Cape Cod, MA, USA) according to the manufacturer's instructions applied to serum sample examination. Results. - The BG levels in BAL samples from the PCP patient group (mean value 20 588 pg/mL) were significantly higher than those in the colonized patient group (mean value 105 pg/mL) (P = 0.0001, Mann-Whitney test) and than those in the Pneumocystis-uninfected patient group (mean value 74 pg/mL) (P < 0.0001, Mann Whitney test). The BG levels in BAL samples from the colonized patient group did not differ significantly from those in the Pneumocystis-uninfected patients group (P = 0.21). Conclusion. - The results suggest that measurements of BAL BG levels may facilitate the differential diagnosis of PCP and pulmonary colonization with Pneumocystis. (C) 2014 Elsevier Masson SAS. All rights reserved.
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https://hal-u-picardie.archives-ouvertes.fr/hal-03555704
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Soumis le : jeudi 3 février 2022 - 17:30:35
Dernière modification le : vendredi 25 mars 2022 - 18:12:15

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C. Damiani, S. Le Gal, N. Goin, P. Di Pizio, C. da Costa, et al.. Usefulness of (1,3) beta-D-glucan detection in bronchoalveolar lavage samples in Pneumocystis pneumonia and Pneumocystis pulmonary colonization. Journal de Mycologie Medicale, 2015, 25 (1), pp.36-43. ⟨10.1016/j.mycmed.2014.11.001⟩. ⟨hal-03555704⟩

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