Arrêt de service programmé du vendredi 10 juin 16h jusqu’au lundi 13 juin 9h. Pour en savoir plus
Accéder directement au contenu Accéder directement à la navigation
Article dans une revue

Non-classical effects of vitamin D: Non-bone effects of vitamin D

Abstract : Our understanding of vitamin D has improved considerably in recent years. The role of vitamin D in preventing osteoporotic fractures is now well-established. However, an important controversy has emerged in the last decade concerning the effects of the active form of vitamin D (1,25-dihydroxy-vitamin D) on tissues other than bone (non-classical effects). The demonstration that the vitamin D receptor (VDR) is ubiquitously, expressed combined with increasing observational data supporting a relationship between the level of 25-hydroxy-vitamin D in the serum and chronic metabolic disorders, cardiovascular disease and neoplasms, have led to its redefinition as a steroid hormone and the proposal of its use in preventing and/or treating those diseases. This article is an update on the different non-bone or non-classical effects of ``vitamin-hormone D'', and its potential preventive or therapeutic role in certain diseases, however, this review is not exhaustive. The different modalities of substitution or supplementation proposed in France by the Groupe de Recherche et d'Information sur les Osteoporoses (GRIO) are also summarised. (C) 2020 Elsevier Masson SAS. All rights reserved.
Type de document :
Article dans une revue
Liste complète des métadonnées

https://hal-u-picardie.archives-ouvertes.fr/hal-03555790
Contributeur : Louise Dessaivre Connectez-vous pour contacter le contributeur
Soumis le : jeudi 3 février 2022 - 18:26:19
Dernière modification le : jeudi 31 mars 2022 - 11:00:02

Lien texte intégral

Identifiants

Citation

Antoine-Guy Lopez, Veronique Kerlan, Rachel Desailloud. Non-classical effects of vitamin D: Non-bone effects of vitamin D. Annales d'Endocrinologie, Elsevier Masson, 2021, 82 (1), pp.43-51. ⟨10.1016/j.ando.2020.12.002⟩. ⟨hal-03555790⟩

Partager

Métriques

Consultations de la notice

16