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Article Dans Une Revue Virology Année : 2018

Coxsackievirus-B4E2 can infect monocytes and macrophages in vitro and in vivo

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M. A. Benkahla
  • Fonction : Auteur
F. Elmastour
  • Fonction : Auteur
F. Sane
  • Fonction : Auteur
A-C Vreulx
  • Fonction : Auteur
I Engelmann
  • Fonction : Auteur
H. Jaidane
  • Fonction : Auteur
E. K. Alidjinou
  • Fonction : Auteur

Résumé

Viral RNA (vRNA) is found in mice inoculated with coxsackievirus-B4E2 (CV-B4E2). The CV-B4E2 infection of murine spleen cells in vitro is enhanced with CV-B4E2-infected mouse serum. It has been investigated whether monocyte/macrophages were targets of CV-B4E2 in mice. vRNA has been detected in spleen and bone marrow of infected animals. The levels of vRNA were higher in CD14 + cells than in CD14- spleen cells and in F4/80- cells than in F4/80 + spleen cells. Meanwhile, CD14 + cells and F4/80- cells were more permissive to CV-B4E2 in vitro and the infection was enhanced when the virus was mixed with immune serum. While CV-B4E2 infected BMDM cultures (98% F4/80 +); however, the immune serum did not enhance the infection. In conclusion, CV-B4E2 infects monocytes (CD14 +, F4/80-) and macrophages (CD14 +, F4/80 +) in vivo and immune serum can enhance the in vitro infection of these cells arising out of the spleen.

Dates et versions

hal-03555798 , version 1 (03-02-2022)

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Citer

M. A. Benkahla, F. Elmastour, F. Sane, A-C Vreulx, I Engelmann, et al.. Coxsackievirus-B4E2 can infect monocytes and macrophages in vitro and in vivo. Virology, 2018, 522, pp.271-280. ⟨10.1016/j.virol.2018.06.010⟩. ⟨hal-03555798⟩
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