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Coxsackievirus-B4E2 can infect monocytes and macrophages in vitro and in vivo

Abstract : Viral RNA (vRNA) is found in mice inoculated with coxsackievirus-B4E2 (CV-B4E2). The CV-B4E2 infection of murine spleen cells in vitro is enhanced with CV-B4E2-infected mouse serum. It has been investigated whether monocyte/macrophages were targets of CV-B4E2 in mice. vRNA has been detected in spleen and bone marrow of infected animals. The levels of vRNA were higher in CD14 + cells than in CD14- spleen cells and in F4/80- cells than in F4/80 + spleen cells. Meanwhile, CD14 + cells and F4/80- cells were more permissive to CV-B4E2 in vitro and the infection was enhanced when the virus was mixed with immune serum. While CV-B4E2 infected BMDM cultures (98% F4/80 +); however, the immune serum did not enhance the infection. In conclusion, CV-B4E2 infects monocytes (CD14 +, F4/80-) and macrophages (CD14 +, F4/80 +) in vivo and immune serum can enhance the in vitro infection of these cells arising out of the spleen.
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https://hal-u-picardie.archives-ouvertes.fr/hal-03555798
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Soumis le : jeudi 3 février 2022 - 18:26:28
Dernière modification le : lundi 29 août 2022 - 17:17:01

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M. A. Benkahla, F. Elmastour, F. Sane, A-C Vreulx, I Engelmann, et al.. Coxsackievirus-B4E2 can infect monocytes and macrophages in vitro and in vivo. Virology, Elsevier, 2018, 522, pp.271-280. ⟨10.1016/j.virol.2018.06.010⟩. ⟨hal-03555798⟩

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