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Article Dans Une Revue Antimicrobial Agents and Chemotherapy Année : 2019

Validation and Application of an HPLC-DAD Method for Routine Therapeutic Drug Monitoring of Ceftobiprole

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Résumé

Ceftobiprole is a fifth-generation cephalosporin approved for the treatment of pneumonia, with a broad antibacterial spectrum, including potent activity against methicillin-resistant Staphylococcus aureus. As for the other cephalosporins, high pharmacokinetic variability and concentration-dependent neurotoxicity are expected. We describe here the first simple and rapid analytical method intended for ceftobiprole serum concentration monitoring. We report the data of 5 patients treated with ceftobiprole, among who 2 developed reversible neurological disorders with high ceftobiprole serum concentration.

Dates et versions

hal-03564805 , version 1 (10-02-2022)

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Citer

Benjamin Lima, Sandra Bodeau, Marie-Charlotte Quinton, Cyril Leven, Anne-Sophie Lemaire-Hurtel, et al.. Validation and Application of an HPLC-DAD Method for Routine Therapeutic Drug Monitoring of Ceftobiprole. Antimicrobial Agents and Chemotherapy, 2019, 63 (7), ⟨10.1128/AAC.00515-19⟩. ⟨hal-03564805⟩

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