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Ischaemic colitis associated with intravitreal administration of aflibercept: A first case report

Abstract : In patients with age-related macular degeneration (AMD), the intravitreal injection of antivascular endothelial growth factor (anti-VEGF) agents reduces disease progression and choroidal neovascularization. We report on a first case of ischaemic colitis associated with intravitreal injection of the anti-VEGF agent aflibercept in an 80-year-old female patient. Conservative treatment resulted in a favourable clinical outcome. The anti-VEGF agent was discontinued, and the symptoms did not recur. Although the intravitreal injection of anti-VEGF agents has not previously been linked to the occurrence of ischaemic colitis, consideration of aflibercept's pharmacological properties and the chronological relationship between the administration of this anti-VEGF agent and the occurrence of this systemic adverse event are strongly suggestive of a causal relationship in the present case. Although systemic complications have been rarely associated with intravitreal injections of anti-VEGF agents, physicians should be aware that novel adverse events can still occur in AMD patients treated with anti-VEGF agents.
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https://hal-u-picardie.archives-ouvertes.fr/hal-03564806
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Soumis le : jeudi 10 février 2022 - 15:59:03
Dernière modification le : jeudi 25 août 2022 - 11:22:40

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Benjamin Batteux, Valerie Gras, Yanis Mahboud, Sophie Liabeuf, Youssef Bennis, et al.. Ischaemic colitis associated with intravitreal administration of aflibercept: A first case report. British Journal of Clinical Pharmacology, Wiley, 2019, 85 (4), pp.845-848. ⟨10.1111/bcp.13853⟩. ⟨hal-03564806⟩

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