Neurotoxic Concentration of Piperacillin during Continuous Infusion in Critically Ill Patients

Marie-Charlotte Quinton (1) , Sandra Bodeau (2, 3) , Loay Kontar (2) , Yoann Zerbib (1) , Julien Maizel (4, 3) , Michel Slama (2, 3) , Kamel Masmoudi (2) , Anne-Sophie Lemaire-Hurtel (2) , Youssef Bennis (2, 3)

1 UPJV - Université de Picardie Jules Verne
2 CHU Amiens-Picardie
3 MP3CV - Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517
4 BoReal Study Group, Medical Intensive Care Unit and EA7517, Amiens University Hospital, F-80054, Amiens,

This retrospective cohort study included 53 patients admitted to the intensive care unit (ICU), with an average age of 69 years, without neurologic disorder before initiation of a continuous piperacillin infusion at the standard dose and who underwent piperacillin serum concentration monitoring. Among them, 23 developed a neurologic disorder for which the piperacillin causality was chronologically and semiologically suggestive. A concentration threshold of 157.2 mg/liter independently predicted neurotoxicity with 96.7% specificity and 52.2% sensitivity and may constitute a limitation when targeting less susceptible pathogens.

Domaines: Sciences du Vivant [q-bio]

Marie-Charlotte Quinton, Sandra Bodeau, Loay Kontar, Yoann Zerbib, Julien Maizel, et al.. Neurotoxic Concentration of Piperacillin during Continuous Infusion in Critically Ill Patients. Antimicrobial Agents and Chemotherapy, 2017, 61 (9), ⟨10.1128/AAC.00654-17⟩. ⟨hal-03564813⟩