Accéder directement au contenu Accéder directement à la navigation
Article dans une revue

Vascular calcifications, the hidden side effects of vitamin K antagonists

Abstract : Despite the availability of new oral anticoagulants, vitamin K antagonists (VKA, such as fluindione, acenocoumarol or warfarin) remain currently the goal standard medicines for oral prevention or treatment of thromboembolic disorders. They inhibit the cycle of the vitamin K and its participation in the enzymatic gamma-carboxylation of many proteins. The VKA prevent the activation of the vitamin K-dependent blood clotting factors limiting thus the initiation of the coagulation cascade. But other proteins are vitamin K-dependent and also remain inactive in the presence of VKA. This is the case of matrix Gla-protein (MGP), a protein that plays a major inhibitory role in the development of vascular calcifications. Several experimental and epidemiological results suggest that the use of the VKA could promote the development of vascular calcifications increasing thus the cardiovascular risk. This risk seems to be higher in patients with chronic kidney disease or mellitus diabetes who are more likely to develop vascular calcifications, and may be due to a decrease of the MGP activity. This review aims at summarizing the data currently available making vascular calcifications the probably underestimated side effects of VKA. (C) 2016 Societe francaise de pharmacologie et de therapeutique. Published by Elsevier Masson SAS. All rights reserved.
Type de document :
Article dans une revue
Liste complète des métadonnées

https://hal-u-picardie.archives-ouvertes.fr/hal-03564817
Contributeur : Louise Dessaivre Connectez-vous pour contacter le contributeur
Soumis le : jeudi 10 février 2022 - 15:59:20
Dernière modification le : mercredi 4 mai 2022 - 16:48:02

Identifiants

Collections

Citation

Youssef Bennis, Subashini Vengadessane, Sandra Bodeau, Valerie Gras, Giampiero Bricca, et al.. Vascular calcifications, the hidden side effects of vitamin K antagonists. Therapie, 2016, 71 (4), pp.355-363. ⟨10.1016/j.therap.2015.12.004⟩. ⟨hal-03564817⟩

Partager

Métriques

Consultations de la notice

6