New Insights into the Roles of Monocytes/Macrophages in Cardiovascular Calcification Associated with Chronic Kidney Disease

Lucie Henaut (1) , Alexandre Candellier (1, 2) , Cedric Boudot (1) , Maria Grissi (1) , Romuald Mentaverri (1, 2) , Gabriel Choukroun (2, 1) , Michel Brazier (1, 2) , Saïd Kamel (1, 2) , Ziad A. Massy (3, 4)

1 MP3CV - Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517
2 CHU Amiens-Picardie
3 Hôpital Ambroise Paré [AP-HP]
4 CESP - Centre de recherche en épidémiologie et santé des populations

Cardiovascular disease (CVD) is an important cause of death in patients with chronic kidney disease (CKD), and cardiovascular calcification (CVC) is one of the strongest predictors of CVD in this population. Cardiovascular calcification results from complex cellular interactions involving the endothelium, vascular/valvular cells (i.e., vascular smooth muscle cells, valvular interstitial cells and resident fibroblasts), and monocyte-derived macrophages. Indeed, the production of pro-inflammatory cytokines and oxidative stress by monocyte-derived macrophages is responsible for the osteogenic transformation and mineralization of vascular/valvular cells. However, monocytes/macrophages show the ability to modify their phenotype, and consequently their functions, when facing environmental modifications. This plasticity complicates efforts to understand the pathogenesis of CVC-particularly in a CKD setting, where both uraemic toxins and CKD treatment may affect monocyte/macrophage functions and thereby influence CVC. Here, we review (i) the mechanisms by which each monocyte/macrophage subset either promotes or prevents CVC, and (ii) how both uraemic toxins and CKD therapies might affect these monocyte/macrophage functions.

Mots clés: cardiovascular calcification; chronic kidney disease; macrophages; monocytes; uraemic toxins

Domaines: Sciences du Vivant [q-bio]

Lucie Henaut, Alexandre Candellier, Cedric Boudot, Maria Grissi, Romuald Mentaverri, et al.. New Insights into the Roles of Monocytes/Macrophages in Cardiovascular Calcification Associated with Chronic Kidney Disease. Toxins, 2019, 11 (9), ⟨10.3390/toxins11090529⟩. ⟨hal-03564970⟩