A 4 day-clinical microdialysis monitoring in a patient with traumatic brain injury (tbi) suggests a possible link between brain serotonin and cerebral energy metabolism

B. Renaud (1) , S. Parrot (2) , D. Goncalves (1) , M. Algoud (1) , Marlène Gallet (2) , F. Dailler (3) , L. Denoroy (2)

1 HCL - Hospices Civils de Lyon, Departement de Neurologie
2 CRNL - Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center
3 Intensive Care Unit, Neurological Hospital

While the continuous microdialysis monitoring of cerebral biomarkers of energy metabolism is frequently used in neurocritical care, very few data on monoamine neurotransmitters, such as serotonin (5-HT), have been reported using clinical microdialysis. Consequently, taking the opportunity of a feasibility study for a project on TBI, we sought to determine 5-HT levels in the brain microdialysis samples obtained from a TBI patient, concomitantly with biomarkers of energy metabolism.

Domaines: Sciences du Vivant [q-bio]

B. Renaud, S. Parrot, D. Goncalves, M. Algoud, Marlène Gallet, et al.. A 4 day-clinical microdialysis monitoring in a patient with traumatic brain injury (tbi) suggests a possible link between brain serotonin and cerebral energy metabolism. 27th International Symposium on Cerebral Blood Flow, Metabolism and Function / 12th International Conference on Quantification of Brain Function with PET, Jun 2015, Vancouver, Canada. Journal of Cerebral Blood Flow & Metabolism (Poster Abstracts), 36 (1s), pp.725, 2016, ⟨10.1177/0271678X16639008⟩. ⟨hal-03565048⟩