A 4 day-clinical microdialysis monitoring in a patient with traumatic brain injury (tbi) suggests a possible link between brain serotonin and cerebral energy metabolism

Abstract : While the continuous microdialysis monitoring of cerebral biomarkers of energy metabolism is frequently used in neurocritical care, very few data on monoamine neurotransmitters, such as serotonin (5-HT), have been reported using clinical microdialysis. Consequently, taking the opportunity of a feasibility study for a project on TBI, we sought to determine 5-HT levels in the brain microdialysis samples obtained from a TBI patient, concomitantly with biomarkers of energy metabolism.