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Vasoplegia After Cardiac Surgery Is Associated With Endothelial Glycocalyx Alterations

Abstract : Objective: To assess endothelial glycocalyx (EG) alteration in vasoplegic syndrome after cardiac surgery with cardiopulmonary bypass. Design: Prospective analysis Setting: Single university hospitals. Participants: Patients undergoing elective cardiac surgery under cardiopulmonary bypass. Interventions: Observational study Methods: Heparan sulfate and syndecan-1 levels were assessed in plasma before surgery, on intensive care unit admission, and on the first postoperative day. The primary outcome was comparisons of heparan sulfate and syndecan-1 levels in patients with and without vasoplegic syndrome. Results: A total of 46 patients were analyzed. Only syndecan-1 was modified by cardiac surgery (p < 0.05). Plasma syndecan-1 levels were lower in patients with vasoplegic syndrome at the 3 time-points and were associated with the cumulative norepinephrine dose. Baseline plasma syndecan-1 predicted the development of vasoplegic syndrome with an area under the curve of 0.7 (confidence interval 95%: 0.51-0.85, p = 0.045). Heparan sulfate levels were not modified by cardiac surgery. Conclusion: Patients with vasoplegic syndrome after cardiac surgery present a different pattern of EG components. Lower syndecan-1 levels were associated with vasoplegic syndrome. These preliminary results suggest a specific phenotype that may reflect endothelial activation leading to alteration of the EG. (C) 2019 Elsevier Inc. All rights reserved.
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Soumis le : jeudi 10 février 2022 - 17:58:45
Dernière modification le : vendredi 26 août 2022 - 16:28:49

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Osama Abou-Arab, Saïd Kamel, Christophe Beyls, Pierre Huette, Stephane Bar, et al.. Vasoplegia After Cardiac Surgery Is Associated With Endothelial Glycocalyx Alterations. Journal of Cardiothoracic and Vascular Anesthesia, WB Saunders, 2020, 34 (4), pp.900-905. ⟨10.1053/j.jvca.2019.09.004⟩. ⟨hal-03565101⟩

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