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Article Dans Une Revue Toxins Année : 2016

N-methyl-2-pyridone-5-carboxamide (2PY)-Major Metabolite of Nicotinamide: An Update on an Old Uremic Toxin

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Résumé

N-methyl-2-pyridone-5-carboxamide (2PY, a major metabolite of nicotinamide, NAM) was recently identified as a uremic toxin. Recent interventional trials using NAM to treat high levels of phosphorus in end-stage renal disease have highlighted new potential uremic toxicities of 2PY. In the context of uremia, the accumulation of 2PY could be harmful-perhaps by inhibiting poly (ADP-ribose) polymerase-1 activity. Here, we review recently published data on 2PY's metabolism and toxicological profile.

Dates et versions

hal-03568256 , version 1 (12-02-2022)

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Aurelie Lenglet, Sophie Liabeuf, Sandra Bodeau, Loïc Louvet, Aurelien Mary, et al.. N-methyl-2-pyridone-5-carboxamide (2PY)-Major Metabolite of Nicotinamide: An Update on an Old Uremic Toxin. Toxins, 2016, 8 (11), ⟨10.3390/toxins8110339⟩. ⟨hal-03568256⟩
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