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Article dans une revue

The Impact of Uremic Toxins on Cerebrovascular and Cognitive Disorders

Abstract : Individuals at all stages of chronic kidney disease (CKD) have a higher risk of developing cognitive disorders and dementia. Stroke is also highly prevalent in this population and is associated with a higher risk of neurological deterioration, in-hospital mortality, and poor functional outcomes. Evidence from in vitro studies and in vivo animal experiments suggests that accumulation of uremic toxins may contribute to the pathogenesis of stroke and amplify vascular damage, leading to cognitive disorders and dementia. This review summarizes current evidence on the mechanisms by which uremic toxins may favour the occurrence of cerebrovascular diseases and neurological complications in CKD.
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Soumis le : lundi 14 février 2022 - 11:42:45
Dernière modification le : vendredi 5 août 2022 - 11:25:21

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Maryam Assem, Mathilde Lando, Maria Grissi, Saïd Kamel, Ziad A. Massy, et al.. The Impact of Uremic Toxins on Cerebrovascular and Cognitive Disorders. Toxins, MDPI, 2018, 10 (7), ⟨10.3390/toxins10070303⟩. ⟨hal-03572447⟩



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