Arrêt de service programmé du vendredi 10 juin 16h jusqu’au lundi 13 juin 9h. Pour en savoir plus
Accéder directement au contenu Accéder directement à la navigation
Article dans une revue

Updates on the Mechanisms and the Care of Cardiovascular Calcification in Chronic Kidney Disease

Abstract : In chronic kidney disease (CKD), the progressive decrease in renal function leads to disturbances of mineral metabolism that generally cause secondary hyperparathyroidism. The increase in serum parathyroid hormone is associated with reduced serum calcium and calcitriol levels and/or increased serum fibroblast growth factor-23 and phosphate levels. The resulting CKD-associated disorder of mineral and bone metabolism is associated with various other metabolic dysregulations such as acidosis, malnutrition, inflammation, and accumulation of uremic toxins. It favors the occurrence of vascular calcification, which results from an imbalance between numerous inhibitors and promoters of soft-tissue mineralization. This review provides an overview of the most recent state of knowledge concerning the mechanisms that lead to the development of vascular calcification in the CKD setting. It further proposes directions for potential new therapeutic targets. Semin Nephrol 38:233-250 (C) 2018 Elsevier Inc. All rights reserved.
Type de document :
Article dans une revue
Liste complète des métadonnées
Contributeur : Louise Dessaivre Connectez-vous pour contacter le contributeur
Soumis le : lundi 14 février 2022 - 11:42:48
Dernière modification le : mercredi 4 mai 2022 - 16:48:02



Lucie Henaut, Jean-Marc Chillon, Saïd Kamel, Ziad A. Massy. Updates on the Mechanisms and the Care of Cardiovascular Calcification in Chronic Kidney Disease. SEMINARS IN NEPHROLOGY, 2018, 38 (3, SI), pp.233-250. ⟨10.1016/j.semnephrol.2018.02.004⟩. ⟨hal-03572449⟩



Consultations de la notice