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Shiga Toxin-Associated Hemolytic Uremic Syndrome in Adults, France, 2009-2017

Abstract : We conducted a retrospective study on hemolytic uremic syndrome caused by Shiga toxin-producing Escherichia coli (STEC) in 96 adults enrolled in the cohort of the National Reference Center for Thrombotic Microangiopathies network in France during 2009-2017. Most infections were caused by STEC strains not belonging to the O157 or O104 serogroups. Thirty (31.3%) patients had multiple risk factors for thrombotic microangiopathy. In total, 61 (63.5%) patients required dialysis, 50 (52.1%) had a serious neurologic complication, 34 (35.4%) required mechanical ventilation, and 19 (19.8%) died during hospitalization. We used multivariate analysis to determine that the greatest risk factors for death were underlying immunodeficiency (hazard ratio 3.54) and severe neurologic events (hazard ratio 3.40). According to multivariate analysis and propensity score-matching, eculizuma b treatment was not associated with survival. We found that underlying conditions, especially immunodeficiency, are strongly associated with decreased survival in adults who have hemolytic uremic syndrome caused by STEC.
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https://hal-u-picardie.archives-ouvertes.fr/hal-03572956
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Soumis le : lundi 14 février 2022 - 14:47:05
Dernière modification le : vendredi 26 août 2022 - 16:00:32

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Benoit Travert, Antoine Dossier, Matthieu Jamme, Aurelie Cointe, Yahsou Delmas, et al.. Shiga Toxin-Associated Hemolytic Uremic Syndrome in Adults, France, 2009-2017. Emerging Infectious Diseases, Centers for Disease Control and Prevention, 2021, 27 (7), pp.1876-1885. ⟨10.3201/eid2707.204638⟩. ⟨hal-03572956⟩

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