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Article dans une revue

Recurrence of Renal Cell Cancer After Renal Transplantation in a Multicenter French Cohort

Abstract : Background. Renal cancer accounts for 3% of adult malignancies; renal cell carcinoma (RCC) represents 80% of all renal cancers, and is characterized by late recurrences. Recurrences after kidney transplantation are associated with a high mortality rate. We aimed to determine if recurrences are linked to tumor characteristics and to delays between diagnosis and transplantation. Methods. We retrospectively analyzed data from French kidney-transplanted patients with medical histories of pretransplant renal cancer, focusing on the most common histological subtypes: clear cell and papillary cancers. Characteristics of the tumors, patients, and kidney transplantations were documented, and posttransplant patient survival was analyzed. Results. Of 143 patients, 13 experienced cancer recurrence after kidney transplantation. The mean delay in recurrence was 3 +/- 2.3 years posttransplantation, and the cumulative incidences of recurrence were 7.7% at 5 years and 14.9% at 10 years. The risk of recurrence was higher in patients with clear cell RCC (13% vs 0%, P = 0.015). There was no correlation between posttransplant recurrence and the interval before transplantation. Factors associated with a higher risk of cancer recurrence were histological clear cell RCC (P = 0.025), tumor stage pT2 (P = 0.002), and Fuhrman grade IV (P < 0.001). Recurrences were associated with a high mortality rate; 76.9% of patients with recurrences had died by the end of the follow-up period. Conclusions. Recurrences of clear cell RCC are not uncommon after kidney transplantation and are associated with very poor prognoses. These results should be considered before listing patients with a history of renal cancer for transplantation.
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Contributeur : Louise DESSAIVRE Connectez-vous pour contacter le contributeur
Soumis le : lundi 14 février 2022 - 15:27:52
Dernière modification le : vendredi 26 août 2022 - 15:32:40




Noelle Cognard, Dany Anglicheau, Philippe Gatault, Sophie Girerd, Marie Essig, et al.. Recurrence of Renal Cell Cancer After Renal Transplantation in a Multicenter French Cohort. Transplantation, Lippincott, Williams & Wilkins, 2018, 102 (5), pp.860-867. ⟨10.1097/TP.0000000000002009⟩. ⟨hal-03573109⟩



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