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Article dans une revue

Early cardiotoxicity of Hydroxychloroquine

Abstract : Introduction. - Hydroxychloroquine (HCQ) is most frequently used in the treatment of systemic inflammatory diseases. Cardiac complications of anti-malarial drugs are uncommon, and most of the time are the result of a long-term exposition. In this case, cardiotoxicity is the consequence of the lysosomal dysfunction and the result of intracytoplasmic granular material inclusions. Case report. - We report a 77-year-old woman who presented a very early and reversible cardiotoxicity, probably related to the quinidine like effect of the HCQ 10 days after initiation of therapy for Whipple endocarditis. Conclusion. - We discuss the different mechanisms of cardiotoxicity of anti-malarial drugs and their clinical manifestations. (C) 2015 Societe nationale francaise de medecine interne (SNFMI). Published by Elsevier Masson SAS. All rights reserved.
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Soumis le : mardi 15 février 2022 - 10:52:05
Dernière modification le : mercredi 24 août 2022 - 11:53:23




Y. Zerbib, M. P. Guillaumont, G. Touati, Pierre Duhaut, Jean Schmidt. Early cardiotoxicity of Hydroxychloroquine. La Revue de Médecine Interne, Elsevier, 2016, 37 (3), pp.209-211. ⟨10.1016/j.revmed.2015.07.011⟩. ⟨hal-03574539⟩



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