Early cardiotoxicity of Hydroxychloroquine

Y. Zerbib (1) , M. P. Guillaumont , G. Touati , Pierre Duhaut (1, 2) , Jean Schmidt (1)

1 CHU Amiens-Picardie
2 MP3CV - Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517

Introduction. - Hydroxychloroquine (HCQ) is most frequently used in the treatment of systemic inflammatory diseases. Cardiac complications of anti-malarial drugs are uncommon, and most of the time are the result of a long-term exposition. In this case, cardiotoxicity is the consequence of the lysosomal dysfunction and the result of intracytoplasmic granular material inclusions. Case report. - We report a 77-year-old woman who presented a very early and reversible cardiotoxicity, probably related to the quinidine like effect of the HCQ 10 days after initiation of therapy for Whipple endocarditis. Conclusion. - We discuss the different mechanisms of cardiotoxicity of anti-malarial drugs and their clinical manifestations. (C) 2015 Societe nationale francaise de medecine interne (SNFMI). Published by Elsevier Masson SAS. All rights reserved.

Domaines: Sciences du Vivant [q-bio]

Y. Zerbib, M. P. Guillaumont, G. Touati, Pierre Duhaut, Jean Schmidt. Early cardiotoxicity of Hydroxychloroquine. La Revue de Médecine Interne, 2016, 37 (3), pp.209-211. ⟨10.1016/j.revmed.2015.07.011⟩. ⟨hal-03574539⟩