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Article Dans Une Revue La Revue de Médecine Interne Année : 2016

Early cardiotoxicity of Hydroxychloroquine

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Résumé

Introduction. - Hydroxychloroquine (HCQ) is most frequently used in the treatment of systemic inflammatory diseases. Cardiac complications of anti-malarial drugs are uncommon, and most of the time are the result of a long-term exposition. In this case, cardiotoxicity is the consequence of the lysosomal dysfunction and the result of intracytoplasmic granular material inclusions. Case report. - We report a 77-year-old woman who presented a very early and reversible cardiotoxicity, probably related to the quinidine like effect of the HCQ 10 days after initiation of therapy for Whipple endocarditis. Conclusion. - We discuss the different mechanisms of cardiotoxicity of anti-malarial drugs and their clinical manifestations. (C) 2015 Societe nationale francaise de medecine interne (SNFMI). Published by Elsevier Masson SAS. All rights reserved.
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hal-03574539 , version 1 (15-02-2022)

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Y. Zerbib, M. P. Guillaumont, G. Touati, Pierre Duhaut, Jean Schmidt. Early cardiotoxicity of Hydroxychloroquine. La Revue de Médecine Interne, 2016, 37 (3), pp.209-211. ⟨10.1016/j.revmed.2015.07.011⟩. ⟨hal-03574539⟩

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