Early cardiotoxicity of Hydroxychloroquine
Résumé
Introduction. - Hydroxychloroquine (HCQ) is most frequently used in the treatment of systemic inflammatory diseases. Cardiac complications of anti-malarial drugs are uncommon, and most of the time are the result of a long-term exposition. In this case, cardiotoxicity is the consequence of the lysosomal dysfunction and the result of intracytoplasmic granular material inclusions. Case report. - We report a 77-year-old woman who presented a very early and reversible cardiotoxicity, probably related to the quinidine like effect of the HCQ 10 days after initiation of therapy for Whipple endocarditis. Conclusion. - We discuss the different mechanisms of cardiotoxicity of anti-malarial drugs and their clinical manifestations. (C) 2015 Societe nationale francaise de medecine interne (SNFMI). Published by Elsevier Masson SAS. All rights reserved.