Multinational Observational Cohort Study of COVID-19-Associated Pulmonary Aspergillosis(1)

Nico A. F. Janssen , Remy Nyga (1) , Lore Vanderbeke , Cato Jacobs , Mehmet Ergun , Jochem B. Buil , Karin Van Dijk , Josje Altenburg , Catherine S. C. Bouman , Hans van Der Spoel , Bart J. A. Rijnders , Albert Dunbar , Jeroen A. Schouten , Katrien Lagrou (2, 3) , Marc Bourgeois (4) , Marijke Reynders , Niels Van Regenmortel , Lynn Rutsaert , Piet Lormans , Simon Feys , Yves Debavaye , Fabienne Tamion (5, 6) , Damien Costa (6) , Julien Maizel (7) , Herve Dupont (8, 7) , Taieb Chouaki (9) , Saad Nseir (10) , Boualem Sendid (10, 11) , Roger J. M. Bruggemann , Frank L. van De Veerdonk , Joost Wauters (2, 3) , Paul E. Verweij (12)

1 Service de Parasitologie-Mycologie [CHRU LIlle]
2 KU Leuven - Catholic University of Leuven - Katholieke Universiteit Leuven
3 University Hospitals Leuven [Leuven]
4 EVS - Environnement, Ville, Société
5 Hôpital Charles Nicolle [Rouen]
6 CHU Rouen
7 MP3CV - Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517
8 CHU Amiens-Picardie
9 Laboratoire de parasitologie et de mycologie médicales [CHU Amiens]
10 CHU Lille
11 Institut de Microbiologie [CHRU Lille]
12 Radboud University Medical Center [Nijmegen]

We performed an observational study to investigate intensive care unit incidence, risk factors, and outcomes of coronavirus disease-associated pulmonary aspergillosis (CAPA). We found 10%-15% CAPA incidence among 823 patients in 2 cohorts. Several factors were independently associated with CAPA in 1 cohort and mortality rates were 43%-52%.

Domaines: Sciences du Vivant [q-bio]

Nico A. F. Janssen, Remy Nyga, Lore Vanderbeke, Cato Jacobs, Mehmet Ergun, et al.. Multinational Observational Cohort Study of COVID-19-Associated Pulmonary Aspergillosis(1). Emerging Infectious Diseases, 2021, 27 (11), pp.2892-2898. ⟨10.3201/eid2711.211174⟩. ⟨hal-03575638⟩