Home Environment as a Source of Life-Threatening Azole-Resistant Aspergillus fumigatus in Immunocompromised Patients

Rose-Anne Lavergne (1) , Taieb Chouaki (2) , Ferry Hagen (3) , Benedicte Toublanc , Herve Dupont (2, 4) , Vincent Jounieaux (2) , Jacques F. Meis (5) , Florent Morio (6) , Patrice Le Pape (7)

1 CPTP - Centre de Physiopathologie Toulouse Purpan
2 CHU Amiens-Picardie
3 Canisius-Wilhelmina Hospital [Nijmegen, The Netherlands]
4 MP3CV - Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517
5 Radboud University Medical Center [Nijmegen]
6 CHU Nantes - Centre Hospitalier Universitaire de Nantes
7 IICiMed - Cibles et Médicaments des Infections et de l'Immunité

A case of fatal aspergillosis due to a TR46/Y121F/T289A azole-resistant Aspergillus fumigatus is reported. Environmental investigations at the patient's residence led to the recovery of TR46/Y121F/T289A isolates, genotypically indistinguishable from the clinical isolate, supporting for the first time the direct role of household as potential source of azole-resistant invasive aspergillosis.

Domaines: Sciences du Vivant [q-bio]

Rose-Anne Lavergne, Taieb Chouaki, Ferry Hagen, Benedicte Toublanc, Herve Dupont, et al.. Home Environment as a Source of Life-Threatening Azole-Resistant Aspergillus fumigatus in Immunocompromised Patients. Clinical Infectious Diseases, 2017, 64 (1), pp.76-78. ⟨10.1093/cid/ciw664⟩. ⟨hal-03577562⟩