Mechanism of Dyspnea during Exercise in Children with Corrected Congenital Heart Disease

Mohamed Mustapha Ammar , Noureddine Ben Said , Levushkin Sergey , Said Ahmaidi (1) , Fawaz Alassery , Habib Hamam (2) , Mehdi Chlif

1 APERE - Adaptations Physiologiques à l'Exercice et Réadaptation à l'effort - UR UPJV 3300
2 Département de génie électrique (Université de Moncton)

This study will evaluate cardiorespiratory and peripheral muscle function and their relationship with subjective dyspnea threshold after the surgical correction of congenital heart disease in children. Thirteen children with surgically repaired congenital heart disease were recruited. Each participant performed an incremental exercise test on a cycle ergometer until exhaustion. Gas exchanges were continuously sampled to measure the maximal aerobic parameters and ventilatory thresholds. The functional capacity of the subjects was assessed with a 6 min walk test. At the end of the exercise test, isokinetic Cybex Norm was used to evaluate the strength and endurance of the knee extensor muscle in the leg. Dyspnea was subjectively scored with a visual analog scale during the last 15 s of each exercise step. Oxygen consumption measured at the dyspnea score/VO2 relationship located at the dyspnea threshold, at which dyspnea suddenly increased. Results: The maximal and submaximal values of the parameters describing the exercise and the peripheral muscular performances were: VO2 Peak: 33.8 +/- 8.9 mL center dot min(-1)center dot kg(-1); HR: 174 +/- 9 b center dot min(-1); VEmax: 65.68 +/- 15.9 L center dot min(-1); P max: 117 +/- 27 W; maximal voluntary isometric force MVIF: 120.8 +/- 41.9 N/m; and time to exhaustion Tlim: 53 +/- 21 s. Oxygen consumption measured at the dyspnea threshold was related to VO2 Peak (R-2 = 0.74; p < 0.01), Tlim (R-2 = 0.78; p < 0.01), and the distance achieved during the 6MWT (R-2 = 0.57; p < 0.05). Compared to the theoretical maximal values for the power output, VO2, and HR, the surgical correction did not repair the exercise performance. After the surgical correction of congenital heart disease, exercise performance was impeded by alterations of the cardiorespiratory function and peripheral local factors. A subjective evaluation of the dyspnea threshold is a reliable criterion that allows the prediction of exercise capacity in subjects suffering from congenital heart disease.

Domaines: Sciences du Vivant [q-bio]

Mohamed Mustapha Ammar, Noureddine Ben Said, Levushkin Sergey, Said Ahmaidi, Fawaz Alassery, et al.. Mechanism of Dyspnea during Exercise in Children with Corrected Congenital Heart Disease. International Journal of Environmental Research and Public Health, 2022, 19 (1), ⟨10.3390/ijerph19010099⟩. ⟨hal-03578204⟩