From old uraemic toxins to new uraemic toxins: place of `omics'

Ziad A. Massy (1, 2) , Sophie Liabeuf (3, 4)

1 Hôpital Ambroise Paré [AP-HP]
2 CESP - Centre de recherche en épidémiologie et santé des populations
3 CHU Amiens-Picardie
4 MP3CV - Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517

Uraemic toxins seem to play an important role in the genesis of cardiovascular and renal damage in chronic kidney disease patients. This short article is divided into two thematic sections. The first part focuses on a selection of `old' toxins for which recent data (published between 2016 and 2018) have provided a better understanding of the associated harmful mechanisms and which, in our opinion, nephrologists should be more aware of. The second part highlights new perspectives for identifying and quantifying these compounds using `omics' techniques.

Domaines: Sciences du Vivant [q-bio]

Ziad A. Massy, Sophie Liabeuf. From old uraemic toxins to new uraemic toxins: place of `omics'. Nephrology Dialysis Transplantation, 2018, 33 (3), pp.2-5. ⟨10.1093/ndt/gfy212⟩. ⟨hal-03578865⟩