Can Nuclear Imaging Techniques Predict Patient Outcome and Guide Medical Management in Hereditary Transthyretin Cardiac Amyloidosis? - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Current Cardiology Reports Année : 2018

Can Nuclear Imaging Techniques Predict Patient Outcome and Guide Medical Management in Hereditary Transthyretin Cardiac Amyloidosis?

(1) , (2) , (3) , (4, 5, 6) , (7, 8) , (9)
1
2
3
4
5
6
7
8
9

Résumé

Purpose of Review Nuclear imaging recently gained a key role in the diagnosis and prognostic assessment of transthyretin (TTR)-related cardiac amyloidosis. This review aims at summarizing the state-of-the art regarding the implementation of nuclear imaging in the management of hereditary mutated TTR-cardiac amyloidosis (mTTR-CA). Recent Findings Although cardiac uptake of bone tracers is acknowledged as a specific marker of TTR amyloid cardiac burden, recent studies validated the implementation of bone scan in the flow chart for non-invasive diagnosis and follow-up of CA in multicenter trials. Simultaneously, cardiac denervation evidenced by MIBG scintigraphy proved to be a strong and independent prognostic marker of poor outcome in mTTR-CA. Summary By its unique ability to assess both amyloid burden and cardiac denervation, nuclear imaging may prove useful as part of multimodality imaging tools to trigger treatment initiation and monitoring in patients with mTTR-CA.
Fichier non déposé

Dates et versions

hal-03584150 , version 1 (22-02-2022)

Identifiants

Citer

Vincent Algalarrondo, Eve Piekarski, Ludivine Eliahou, Dominique Le Guludec, Michel Slama, et al.. Can Nuclear Imaging Techniques Predict Patient Outcome and Guide Medical Management in Hereditary Transthyretin Cardiac Amyloidosis?. Current Cardiology Reports, 2018, 20 (5), ⟨10.1007/s11886-018-0976-9⟩. ⟨hal-03584150⟩
6 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook Twitter LinkedIn More