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Article Dans Une Revue La Presse Médicale Année : 2018

Neurobiological bases of alcohol addiction

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Résumé

Alcohol interacts with numerous neurotransmission systems and particularly glutamatergic NMDA receptors and gabaergic GABA(A) receptors. Binge drinking induces both cerebral damages and cognitive deficits. Alcohol addiction is associated with an increase in the activation threshold of dopaminegic neurons and with a negative emotional state. Alcohol addiction is associated with a deficit in inhibitory control and on increase in motivation to drink alcohol. Environemental cues associated with alcohol trigger drinking desire and can induce relapse. Alcohol disturbs synaptic plasticity phenomena within the brain reword system.
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hal-03589631 , version 1 (25-02-2022)

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Mickaël Naassïla. Neurobiological bases of alcohol addiction. La Presse Médicale, 2018, 47 (6), pp.554-564. ⟨10.1016/j.lpm.2017.12.001⟩. ⟨hal-03589631⟩

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