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Thiamine (vitamin B1) treatment in patients with alcohol dependence

Abstract : Thiamine deficiency (vitamin B1) is common in patients with alcohol dependence. Cognitive impairments may be an early consequence of thiamine deficiency. Wernicke's encephalopathy is underdiagnosed and undertreated. In patients with established Wernicke's encephalopathy, parenteral thiamine 200-500 mg three times a day should be given for 3-5 days, followed by oral thiamine 250-1000 mg/day. In patients with suspected Wernicke's encephalopathy, parenteral thiamine 250-300 mg should be given two times a day for 3-5 days, followed by oral thiamine 250-300 mg/day. In patients at high risk of thiamine deficiency, parenteral thiamine 250-500 mg/day should be given for 3-5 days, followed by oral thiamine 250-300 mg/day. In patients at low risk (with uncomplicated alcohol dependence), oral thiamine 250-500 mg/day should be given for 3-5 days, followed by oral thiamine 100-250 mg/day.
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https://hal-u-picardie.archives-ouvertes.fr/hal-03590123
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Soumis le : samedi 26 février 2022 - 16:47:39
Dernière modification le : samedi 27 août 2022 - 14:27:58

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Alain Dervaux, Xavier Laqueille. Thiamine (vitamin B1) treatment in patients with alcohol dependence. La Presse Médicale, Elsevier Masson, 2017, 46 (2, 1), pp.165-171. ⟨10.1016/j.lpm.2016.07.025⟩. ⟨hal-03590123⟩

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