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Late-onset and nonlate-onset schizophrenia: A comparison of clinical characteristics in a multicenter study

C. Passerieux 1 J. Pellerin 2 J. Perlbarg S. Perron A. Petit F. Petitjean 3 C. Portefaix 4 D. Pringuey 5 A. Radtchenko H. Rahiou D. Raucher-Chene 6 A. Rauzy 7 L. Reinheimer M. Renard 8 M. Rene 9 C. E. Rengade P. Reynaud 10 D. Robin 11 C. Rodrigues 12 A. Rollet 13 F. Rondepierre 14 B. Rousselot S. Rubingher G. Saba 15 J. P. Salvarelli J. C. Samuelian C. Scemama-Ammar F. Schurhoff 1, 16 J. P. Schuster D. Sechter B. Segalas T. Seguret A. S. Seigneurie A. Semmak F. Slama S. Taisne M. Taleb J. L. Terra D. Thefenne E. Tran R. Tourtauchaux 17 M. N. Vacheron V. Vanhoucke E. Venet 18 H. Verdoux 19 A. Viala G. Vidon M. Vitre J. L. Vurpas C. Wagermez M. Walter 20, 21 X. Zendjidjian 22 Sandra Abou Kassm Frederic Limosin 23 Wadih Naja Pierre Vandel 24 Marina Sanchez-Rico 25 Jesus M. Alvarado Armin Gunten Nicolas Hoertel 23 J. Ades C. Alezrah I Amado G. Amar O. Andrei D. Arbault G. Archambault 26 G. Aurifeuille S. Barriere C. Bera-Potelle Y. Blumenstock H. Bardou M. Bareil-Guerin P. Barrau C. Barrouillet E. Baup N. Bazin 27 B. Beaufils 28 J. Ben Ayed M. Benoit 29 K. Benyacoub T. Bichet F. Blanadet O. Blanc 1, 30, 31 J. Blanc-Comiti D. Boussiron A. M. Bouysse A. Brochard O. Brochart B. Bucheron M. Cabot V Camus 32 J. M. Chabannes V Charlot T. Charpeaud 30, 31 C. Clad-Mor C. Combes 33 M. Comisu B. Cordier 34 F. Costi 35 J. P. Courcelles M. Creixell H. Cuche C. Cuervo-Lombard A. Dammak D. da Rin J. B. Denis 36 H. Denizot 1 A. Deperthuis E. Diers S. Dirami D. Donneau P. Dreano 37 C. Dubertret 38 E. Duprat 39 D. Duthoit C. Fernandez P. Fonfrede N. Freitas P. Gasnier 40 J. Gauillard F. Getten Fabien Gierski 41 F. Godart R. Gourevitch Grassin A. Delyle J. Gremion H. Gres V Griner C. Guerin-Langlois C. Guggiari O. Guillin 42 H. Hadaoui E. Haffen 1, 43 S. Haouzir 44 C. Hanon 23 C. Hazif-Thomas 45 A. Heron 46 B. Hubsch I Jalenques D. Januel 47 A. Kaladjian 48 J. F. Karnycheff O. Kebir 25, 49, 50 M. O. Krebs C. Lajugie M. Leboyer 1 P. Legrand 51 M. Lejoyeux V Lemaire E. Leroy 52 D. Levy-Chavagnat A. Leydier 53 C. Liling P. M. Llorca 17 P. Loeffel P. Louville 54 Lucas S. Navarro N. Mages M. Mahi O. Maillet A. Manetti C. Martelli 55, 56, 57 P. Martin 58 M. Masson 59 I Maurs-Ferrer J. Mauvieux S. Mazmanian E. Mechin L. Mekaoui M. Meniai A. Metton A. Mihoubi 60 M. Miron G. Mora Niro Ades P. Nubukpo C. Omnes S. Papin P. Paris 61
14 MMCI - Modélisation de la matière condensée et des interfaces
ILM - Institut Lumière Matière [Villeurbanne]
Abstract : Objectives Data are scarce regarding the potential clinical differences between non-late onset schizophrenia (NLOS, i.e., disorder occurring before 40 years of age), late-onset schizophrenia (LOS, occurring between ages 40 and 60 years) and very-late-onset schizophrenia-like psychosis (VLOSLP, occurring after 60 years of age). Furthermore, previous research compared LOS patients with non-age matched NLOS patients. In this study, we sought to examine potential clinical differences between patients of similar age with LOS and NLOS. Methods/Design This is a cross-sectional multicentre study that recruited in- and outpatients older adults (aged >= 55 years) with an ICD-10 diagnosis of schizophrenia or schizoaffective disorder with NLOS and LOS. Sociodemographic and clinical characteristics, comorbidity, psychotropic medications, quality of life, functioning, and mental health care utilization were drawn for comparison. Results Two hundred seventy-two participants (79.8%) had NLOS, 61 (17.9%) LOS, and 8 (2.3%) VLOSLP. LOS was significantly and independently associated with greater severity of emotional withdrawal and lower severity of depression (all p < 0.05). However, the magnitude of these associations was modest, with significant adjusted odds ratios ranging from 0.71 to 1.24, and there were no significant between-group differences in other characteristics. Conclusion In an age-matched multicenter sample of elderly patients with schizophrenia, older adults with LOS were largely similar to older adults with NLOS in terms of clinical characteristics. The few differences observed may be at least partially related to symptom fluctuation with time. Implications of these findings for pharmacological and nonpharmacological management is yet to be determined.
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https://hal-u-picardie.archives-ouvertes.fr/hal-03590151
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Soumis le : samedi 26 février 2022 - 17:27:51
Dernière modification le : dimanche 1 mai 2022 - 03:17:52

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C. Passerieux, J. Pellerin, J. Perlbarg, S. Perron, A. Petit, et al.. Late-onset and nonlate-onset schizophrenia: A comparison of clinical characteristics in a multicenter study. International Journal of Geriatric Psychiatry, 2021, 36 (8), pp.1204-1215. ⟨10.1002/gps.5512⟩. ⟨hal-03590151⟩

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