Accéder directement au contenu Accéder directement à la navigation
Article dans une revue

Mortality risk and antibiotic use for COVID-19 in hospitalized patients over 80

Abstract : Introduction: Patients over 80 years of age are more prone to develop severe symptoms and die from COVID-19. Antibiotics were massively prescribed in the first days of the pandemic without evidence of super infection. Antibiotics may increase the risk of mortality in cases of viral pneumonia. With age and antibiotic use, the microbiota becomes altered and less protective effect against lethal viral pneumonia. Thus we assessed whether it is safe to prescribe antibiotics for COVID-19 pneumonia to patients over 80 years of age. Method: We conducted a retrospective monocentric study in a 1240-bed university hospital. Our inclusion criteria were patients aged >= 80 years, hospitalized in a COVID-19 unit, with either a positive SARS-CoV-2 RT-PCR from a nasopharyngeal swab or a CT scan within 72 h after or prior to hospitalization in the unit suggestive of infection. Results: We included 101 patients who received antibiotics and 48 who did not. The demographics in the two groups were similar. Overall mortality was higher for the group that received antibiotics than for the other group (36.6% vs 14.6%,). According to univariate COX analysis, the risk of mortality was higher (HR = 1.98 [0.926; 4.23]) but non-significantly for the antibiotic group. In multivariate analysis, independent risk factors of mortality were an increased leukocyte count and decreased oxygen saturation (HR = 1.097 [1.022; 1.178] and HR = 0.927 [0.891; 0.964], respectively). Conclusion: This study raises questions about the interest of antibiotic therapy, its efficacy, and its effect on COVID-19 and encourages further research.
Type de document :
Article dans une revue
Liste complète des métadonnées

https://hal-u-picardie.archives-ouvertes.fr/hal-03590732
Contributeur : Louise DESSAIVRE Connectez-vous pour contacter le contributeur
Soumis le : lundi 28 février 2022 - 10:20:04
Dernière modification le : vendredi 5 août 2022 - 11:26:05

Lien texte intégral

Identifiants

Collections

Citation

Andreea Rosca, Thibaut Balcaen, Jean-Philippe Lanoix, Audrey Michaud, Julien Moyet, et al.. Mortality risk and antibiotic use for COVID-19 in hospitalized patients over 80. Biomedicine and Pharmacotherapy, Elsevier, 2022, 146, ⟨10.1016/j.biopha.2021.112481⟩. ⟨hal-03590732⟩

Partager

Métriques

Consultations de la notice

16