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Combined treatment of refractory ascites with an alfapump (R) plus hernia repair in the same surgical session: A retrospective, multicentre, European pilot study in cirrhotic patients

Abstract : Introduction: The treatment of symptomatic hernia in cirrhotic patients with refractory ascites is critical but challenging. The objective of this study was to assess the feasibility and safety of the implantation of alfapump (R) combined with concomitant hernia repair in cirrhotic patients with refractory ascites. Methods: Using data from six European centres, we retrospectively compared patients treated with alfapump (R) system implantation and concomitant hernia repair [the combined treatment group (CT group, n = 12)] or with intermittent paracentesis hernia repair [the standard treatment group (ST group, n = 26)]. Some patients of the ST group had hernia repair in an elective setting (STel group) and others in emergency (STem group). The endpoints were requirement of peritoneal drainage, the rate of infectious complications, the in-hospital mortality, the length of stay, paracentesis-free survival. Results: Postoperatively, none of the patients in the CT group and 21 patients (80%) in the ST group underwent peritoneal drainage for the evacuation of ascites fluid (P < 0.0001). The overall incidence of infectious complications was not different between groups but there were fewer infections in the CT group than in the STem group (33% vs. 81%; P = 0.01). There was no difference for in-hospital mortality. The length of stay was shorter in the CT group (P = 0.03). Paracentesis-free survival was significantly better (P = 0.0003) in the CT group than in the ST group. Conclusion: Implantation of alfapump combined with concomitant hernia repair seems feasible and safe in cirrhotic patients; however, larger and randomized study are required. (C) 2020 Published by Elsevier Masson SAS.
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https://hal-u-picardie.archives-ouvertes.fr/hal-03590854
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Soumis le : lundi 28 février 2022 - 11:10:59
Dernière modification le : mardi 1 mars 2022 - 03:28:52

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Eric Nguyen-Khac, R. Sarba, L. Spahr, W. Staszewicz, A. Degottardi, et al.. Combined treatment of refractory ascites with an alfapump (R) plus hernia repair in the same surgical session: A retrospective, multicentre, European pilot study in cirrhotic patients. Journal of Visceral Surgery, 2021, 158 (1), pp.27-37. ⟨10.1016/j.jviscsurg.2020.06.003⟩. ⟨hal-03590854⟩

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