Accéder directement au contenu Accéder directement à la navigation
Article dans une revue

Indoleamine 2,3-Dioxygenase Is Involved in Interferon Gamma's Anti-BKPyV Activity in Renal Cells

Abstract : Reactivation of BK polyomavirus (BKPyV) infection is frequently increasing in transplant recipients treated with potent immunosuppressants and highlights the importance of immune system components in controlling viral reactivation. However, the immune response to BKPyV in general and the role of antiviral cytokines in infection control in particular are poorly understood. Here, we investigated the efficacy of interferons (IFN) alpha, lambda and gamma with regard to the BKPyV multiplication in Vero cells. Treatment with IFN-gamma inhibited the expression of the viral protein VP1 in a dose-dependent manner and decreased the expression of early and late viral transcripts. Viral inhibition by IFN-gamma was confirmed in human cells (Caki-1 cells and renal proximal tubular epithelial cells). One of the IFN-stimulated genes most strongly induced by IFN-gamma was the coding for the enzyme indoleamine 2,3 dioxygenase (IDO), which is known to limit viral replication and regulates the host immune system. The antiviral activity induced by IFN-gamma could be reversed by the addition of an IDO inhibitor, indicating that IDO has a specific role in anti-BKPyV activity. A better understanding of the action mechanism of these IFN-gamma-induced antiviral proteins might facilitate the development of novel therapeutic strategies.
Type de document :
Article dans une revue
Liste complète des métadonnées

https://hal-u-picardie.archives-ouvertes.fr/hal-03591567
Contributeur : Louise DESSAIVRE Connectez-vous pour contacter le contributeur
Soumis le : lundi 28 février 2022 - 16:38:44
Dernière modification le : vendredi 2 septembre 2022 - 18:16:22

Lien texte intégral

Identifiants

Collections

Citation

Tony Fiore, Elodie Martin, Veronique Descamps, Etienne Brochot, Virginie Morel, et al.. Indoleamine 2,3-Dioxygenase Is Involved in Interferon Gamma's Anti-BKPyV Activity in Renal Cells. Viruses, MDPI, 2020, 12 (8), ⟨10.3390/v12080865⟩. ⟨hal-03591567⟩

Partager

Métriques

Consultations de la notice

10