Accéder directement au contenu Accéder directement à la navigation
Article dans une revue

Biology of the BKPyV: An Update

Abstract : The BK virus (BKPyV) is a member of the Polyomaviridae family first isolated in 1971. BKPyV causes frequent infections during childhood and establishes persistent infections with minimal clinical implications within renal tubular cells and the urothelium. However, reactivation of BKPyV in immunocompromised individuals may cause serious complications. In particular, with the implementation of more potent immunosuppressive drugs in the last decade, BKPyV has become an emerging pathogen in kidney and bone marrow transplant recipients where it often causes associated nephropathy and haemorrhagic cystitis, respectively. Unfortunately, no specific antiviral against BKPyV has been approved yet and the only therapeutic option is a modulation of the immunosuppressive drug regimen to improve immune control though it may increase the risk of rejection. A better understanding of the BKPyV life cycle is thus needed to develop efficient treatment against this virus. In this review, we provide an update on recent advances in understanding the biology of BKPyV.
Type de document :
Article dans une revue
Liste complète des métadonnées
Contributeur : Louise DESSAIVRE Connectez-vous pour contacter le contributeur
Soumis le : lundi 28 février 2022 - 16:38:54
Dernière modification le : vendredi 2 septembre 2022 - 18:16:22

Lien texte intégral




Francois Helle, Etienne Brochot, Lynda Handala, Elodie Martin, Sandrine Castelain, et al.. Biology of the BKPyV: An Update. Viruses, MDPI, 2017, 9 (11), ⟨10.3390/v9110327⟩. ⟨hal-03591576⟩



Consultations de la notice