Arrêt de service programmé du vendredi 10 juin 16h jusqu’au lundi 13 juin 9h. Pour en savoir plus
Accéder directement au contenu Accéder directement à la navigation
Article dans une revue

Drug delivery systems designed to overcome antimicrobial resistance

Abstract : Antimicrobial resistance has emerged as a huge challenge to the effective treatment of infectious diseases. Aside from a modest number of novel anti-infective agents, very few new classes of antibiotics have been successfully developed for therapeutic use. Despite the research efforts of numerous scientists, the fight against antimicrobial (ATB) resistance has been a longstanding continued effort, as pathogens rapidly adapt and evolve through various strategies, to escape the action of ATBs. Among other mechanisms of resistance to antibiotics, the sophisticated envelopes surrounding microbes especially form a major barrier for almost all anti-infective agents. In addition, the mammalian cell membrane presents another obstacle to the ATBs that target intracellular pathogens. To negotiate these biological membranes, scientists have developed drug delivery systems to help drugs traverse the cell wall; these are called ``Trojan horse'' strategies. Within these delivery systems, ATB molecules can be conjugated with one of many different types of carriers. These carriers could include any of the following: siderophores, antimicrobial peptides, cell-penetrating peptides, antibodies, or even nanoparticles. In recent years, the Trojan horse-inspired delivery systems have been increasingly reported as efficient strategies to expand the arsenal of therapeutic solutions and/or reinforce the effectiveness of conventional ATBs against drug-resistant microbes, while also minimizing the side effects of these drugs. In this paper, we aim to review and report on the recent progress made in these newly prevalent ATB delivery strategies, within the current context of increasing ATB resistance.
Type de document :
Article dans une revue
Liste complète des métadonnées

https://hal-u-picardie.archives-ouvertes.fr/hal-03592257
Contributeur : Louise Dessaivre Connectez-vous pour contacter le contributeur
Soumis le : mardi 1 mars 2022 - 10:44:36
Dernière modification le : mercredi 16 mars 2022 - 15:32:03

Identifiants

Collections

Citation

Alexandra Dassonville-Klimpt, Pascal Sonnet, Thanh-Nhat Pham, Pauline Loupias. Drug delivery systems designed to overcome antimicrobial resistance. Medicinal Research Reviews, 2019, 39 (6), pp.2343-2396. ⟨10.1002/med.21588⟩. ⟨hal-03592257⟩

Partager

Métriques

Consultations de la notice

7