Medical versus surgical treatment in native hip and knee septic arthritis

C. Mabille (1) , Y. El Samad , Cédric Joseph (2) , B. Brunschweiler , Vincent Goeb (3) , Franck Grados (4) , Jean-Philippe Lanoix (2)

1 UMR CNRS 8009 - Laboratoire de Chimie Organique et Macromoleculaire
2 AGIR - Agents infectieux, résistance et chimiothérapie - UR UPJV 4294
3 HEMATIM - HEMATIM - Hématopoïèse et immunologie - UR UPJV 4666
4 MP3CV - Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517

Objective: Antibiotic treatment and arthroscopic or open drainage is the gold standard for septic arthritis. Full recovery takes time after surgery and hospital stay is longer than for arthrocentesis at the bedside. We aimed to evaluate the effectiveness of arthrocentesis (medical approach) versus a surgical approach. Method: We retrospectively included 97 cases of native joint arthritis (hip and knee) between 2010 and 2017. The primary outcome was treatment failure of medical and surgical approaches (defined as surgical intervention within 7 days following diagnosis). Risk factors of failure were identified by univariable and multivariable logistic regression. Results: We included 72 cases of knee arthritis, of which 43 and 29 were treated medically and surgically, respectively; 25 cases of hip arthritis, of which 8 and 17 were treated medically and surgically, respectively. Failure was observed in 39.2% of cases in the medical group and in 30.4% in the surgical group (P=0.2) (37.5% vs. 52.9% and 39.5% vs. 17.2% for hip and knee, respectively). The univariate analysis identified age and male sex as risk factors for failure (P=0.048 and P=0.02, respectively), but only age was independently associated with failure (P=0.04). Hospital length of stay was 12 days shorter in the medical group (21 vs. 33 days, P=0.02), sequelae were less frequent and less important in the medical group (31.7% vs. 60%). Conclusion: The medical treatment seems to be as effective as the surgical treatment for native joint septic arthritis with a shorter hospital stay and better functional outcome. Further prospective studies are warranted. (C) 2020 Published by Elsevier Masson SAS.

Domaines: Sciences du Vivant [q-bio]

C. Mabille, Y. El Samad, Cédric Joseph, B. Brunschweiler, Vincent Goeb, et al.. Medical versus surgical treatment in native hip and knee septic arthritis. Infectious Diseases Now, 2021, 51 (2), pp.164-169. ⟨10.1016/j.medmal.2020.04.019⟩. ⟨hal-03592718⟩