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Article Dans Une Revue Clinical Infectious Diseases Année : 2016

Shortening Tuberculosis Treatment With Fluoroquinolones: Lost in Translation?

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Résumé

The disappointing recent failure of fluoroquinolone-containing regimens to shorten the duration of tuberculosis treatment in costly phase 3 trials has raised serious questions about the reliability of preclinical tuberculosis models, especially mice, and the current paradigm of regimen development. Therefore we re-examined data from murine models and early-stage clinical trials on which the pivotal trials were based, concluding that phase 3 trial results were in line with preceding studies. Finally, we offer suggestions for a more efficient and integrated preclinical and clinical regimen development program where quantitative pharmacokinetic and pharmacodynamic models more predictive of curative treatment durations are set forth.

Dates et versions

hal-03592729 , version 1 (01-03-2022)

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Jean-Philippe Lanoix, Richard E. Chaisson, Eric L. Nuermberger. Shortening Tuberculosis Treatment With Fluoroquinolones: Lost in Translation?. Clinical Infectious Diseases, 2016, 62 (4), pp.484-490. ⟨10.1093/cid/civ911⟩. ⟨hal-03592729⟩
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