Arrêt de service programmé du vendredi 10 juin 16h jusqu’au lundi 13 juin 9h. Pour en savoir plus
Accéder directement au contenu Accéder directement à la navigation
Article dans une revue

Therapeutic Management of Pyriform Sinus Cancer: Results of a Single-Center Study of 122 Patients

Abstract : Objective. To analyze the survival rate of a nonselected pyriform sinus cancer population. Study Design. Case series with chart review. Setting. University hospital. Subjects and Methods. A total of 122 patients were included in this study covering the 2002-2008 period. All patients had squamous cell carcinoma originating from the pyriform sinus. Survival and prognostic factors were analyzed. Results. The 3-and 5-year overall survival rates were 39.7% and 2.4%, respectively. The 3-and 5-year survival rates without recurrence were 34% and 27%, respectively. The median survival rates by UICC stage were as follows: stage 1 and 2 patients, 60 months; stage 3, 40 months; stage 4, 19 months. Stage 4 patients had a lower median survival rate than other stages (P =.039). The 5-year survival rate was 46% for patients having T3-T4 operable cancers treated by surgery vs 45% for patients treated by laryngeal conservation protocol (not significant). The 5-year survival rate for patients having nonoperable T4 cancers was 17.2%. The 3-and 5-year overall survival rates of N0 patients was significantly higher than N1 patients (P =.042). N2 and N3 patients had 100% 5-year mortality. Conclusion. This study showed that overall survival and therapeutic management depend on the initial stage of pyriform sinus cancer, notably on the N status. In particular, nonoperable T4 pyriform sinus cancer and N2 and N3 patients had a very poor prognosis. A laryngeal conservation protocol seemed as effective as surgical management in terms of survival.
Type de document :
Article dans une revue
Liste complète des métadonnées

https://hal-u-picardie.archives-ouvertes.fr/hal-03593492
Contributeur : Louise Dessaivre Connectez-vous pour contacter le contributeur
Soumis le : mercredi 2 mars 2022 - 09:26:59
Dernière modification le : jeudi 3 mars 2022 - 03:00:17

Identifiants

Collections

Citation

Jerome Donnadieu, Nathalie Klopp-Dutote, Aurelie Biet-Hornstein, Vladimir Strunski, Geoffrey Mortuaire, et al.. Therapeutic Management of Pyriform Sinus Cancer: Results of a Single-Center Study of 122 Patients. OTOLARYNGOLOGY-HEAD AND NECK SURGERY, 2017, 156 (3), pp.498-503. ⟨10.1177/0194599816686335⟩. ⟨hal-03593492⟩

Partager

Métriques

Consultations de la notice

4