Resensitization to Nivolumab after Intratumoral Chemotherapy in Recurrent Head and Neck Squamous Cell Cancer: A Report of 2 Cases - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Case Reports in Oncology Année : 2020

Resensitization to Nivolumab after Intratumoral Chemotherapy in Recurrent Head and Neck Squamous Cell Cancer: A Report of 2 Cases

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Alexandre Coutte
  • Fonction : Auteur
  • PersonId : 1100561
  • IdRef : 137587589
Aurelie Biet
  • Fonction : Auteur
Claude Krzisch

Résumé

The survival of patients with head and neck squamous cancer with locoregional recurrence is short if salvage surgery or radiation cannot be performed. Systemic chemotherapy based on platinum salts and cetuximab produces only partial and transient responses. Immune checkpoint inhibitors (i.e., nivolumab) lead to a low complete response rate of only about 10%, but in some cases the effects can be long-lasting. Intratumoral chemotherapy (ITC) has been proposed for patients with local recurrence of head and neck squamous cell carcinoma with an objective response rate of 27-50%. However, it often leads to peritumoral tissue necrosis, and the duration of local control is limited. Here, we present 2 patients with head and neck squamous cell cancer whose local recurrences were refractory to intravenous chemotherapy and nivolumab. ITC using nonnecrotizing molecules, associated with nivolumab, led to complete stable local and distant response. ITC seems to trigger tumor resensitization to previously ineffective immunotherapy. This combination deserves an evaluation in the framework of a prospective trial.
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Dates et versions

hal-03598660 , version 1 (02-06-2022)

Identifiants

Citer

Aline Houessinon, Aurelie Moreira, Jérémie Bettoni, Marine Schoonaker, Chloé Sauzay, et al.. Resensitization to Nivolumab after Intratumoral Chemotherapy in Recurrent Head and Neck Squamous Cell Cancer: A Report of 2 Cases. Case Reports in Oncology, 2020, 13 (2), pp.835-842. ⟨10.1159/000507986⟩. ⟨hal-03598660⟩
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