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Squamous Cell Carcinoma Antigen-encoding Genes SERPINB3/B4 as Potentially Useful Markers for the Stratification of HNSCC Tumours

Abstract : Background/Aim: The squamous cell carcinoma antigen (SCCA), encoded by the genes SERPINB3/B4, is a tumour marker produced by head and neck squamous cell carcinoma (HNSCC). We aimed to examine SERPINB3/B4 mRNA levels and its clinical significance in the therapeutic context. Materials and Methods: We retrieved mRNA expression levels, clinical, pathological and genomic data for 520 HNSCC from The Cancer Genome Atlas (TCGA). Results: HNSCC tumours express high levels of SERPINB3/B4 mRNA. SERPINB3 expression differs depending on Human papillomavirus (HPV) infection status, primary tumour location, grade and differentiation, extension to lymph nodes and extracapsular spread. Interestingly, we observed an association between SERPINB3/B4 and the presence of tumour immune infiltrate as well as the expression of the immune checkpoint regulators PDL1/PD-L2 that depended on HPV status. Conclusion: Our findings point to potential interest of SERPINB3/B4 for the stratification of HNSCC patients in the therapeutic context.
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https://hal-u-picardie.archives-ouvertes.fr/hal-03598676
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Soumis le : samedi 5 mars 2022 - 17:54:52
Dernière modification le : vendredi 26 août 2022 - 15:20:22

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Zuzana Saidak, Mony Chenda Morisse, Denis Chatelain, Chloé Sauzay, Aline Houessinon, et al.. Squamous Cell Carcinoma Antigen-encoding Genes SERPINB3/B4 as Potentially Useful Markers for the Stratification of HNSCC Tumours. Anticancer Research, International Institute of Anticancer Research, 2018, 38 (3), pp.1343-1352. ⟨10.21873/anticanres.12357⟩. ⟨hal-03598676⟩

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