Probing Tumour Proteostasis and the UPR with Serum Markers

Antoine Galmiche (1, 2) , Chloé Sauzay (3, 1) , Aline Houessinon (4) , Bruno Chauffert (1, 2) , Olivier Pluquet (5)

1 CHU Amiens-Picardie
2 CHIMERE - CHirurgie, IMagerie et REgénération tissulaire de l’extrémité céphalique - Caractérisation morphologique et fonctionnelle - UR UPJV 7516
3 HEMATIM - HEMATIM - Hématopoïèse et immunologie - UR UPJV 4666
4 UPJV - Université de Picardie Jules Verne
5 IBLI - Institut de biologie de Lille - IBL

Tumour proteostasis and the unfolded protein response (UPR) are emerging drivers of tumour progression and important determinants of clinical efficacy of cancer therapy. Recent findings indicate that they also regulate the production of protein tumour markers. Here, we discuss how this new knowledge opens up new perspectives for cancer therapeutics.

Domaines: Sciences du Vivant [q-bio]

Antoine Galmiche, Chloé Sauzay, Aline Houessinon, Bruno Chauffert, Olivier Pluquet. Probing Tumour Proteostasis and the UPR with Serum Markers. Trends in Cancer, 2016, 2 (5), pp.219-221. ⟨10.1016/j.trecan.2016.04.004⟩. ⟨hal-03598685⟩