Aqueductal Cerebrospinal Fluid Stroke Volume Flow in a Rodent Model of Chronic Communicating Hydrocephalus: Establishing a Homogeneous Study Population for Cerebrospinal Fluid Dynamics Exploration - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue World Neurosurgery Année : 2019

Aqueductal Cerebrospinal Fluid Stroke Volume Flow in a Rodent Model of Chronic Communicating Hydrocephalus: Establishing a Homogeneous Study Population for Cerebrospinal Fluid Dynamics Exploration

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Tito Vivas-Buitrago
  • Fonction : Auteur
Armelle Lokossou
  • Fonction : Auteur
Ignacio Jusue-Torres
  • Fonction : Auteur
Gabriel Pinilla-Monsalve
  • Fonction : Auteur
Ari M. Blitz
  • Fonction : Auteur
Daniel A. Herzka
  • Fonction : Auteur
Jamie Robison
  • Fonction : Auteur
Jiadi Xu
  • Fonction : Auteur
Hugo Guerrero-Cazares
  • Fonction : Auteur
Susumu Mori
  • Fonction : Auteur
Alfredo Quinones-Hinojosa
  • Fonction : Auteur
Daniele Rigamonti
  • Fonction : Auteur

Résumé

BACKGROUND: Idiopathic normal pressure hydrocephalus (iNPH) is a cause of dementia that can be reversed when treated timely with cerebrospinal fluid (CSF) diversion. Understanding CSF dynamics throughout the development of hydrocephalus is crucial to identify prognostic markers to estimate benefit/risk to shunts. OBJECTIVE: To explore the cerebral aqueduct CSF flow dynamics with phase-contrast magnetic resonance imaging (MRI) in a novel rodent model of adult chronic communicating hydrocephalus. METHODS: Kaolin was injected into the subarachnoid space at the convexities in Sprague-Dawley adult rats. 11.7-T Bruker MRI was used to acquire T2-weighted images for anatomic identification and phase-contrast MRI at the cerebral aqueduct. Aqueductal stroke volume (ASV) results were compared with the ventricular volume (VV) at 15, 60, 90, and 120 days. RESULTS: Significant ventricular enlargement was found in kaolin-injected animals at all times (P < 0.001). ASV differed between cases and controls/shams at every time point (P = 0.004, 0.001, 0.001, and <0.001 at 15, 60, 90, and 120 days, respectively). After correlation between the ASV and the VV, there was a significant correlation at 15 (P = 0.015), 60 (P = 0.001), 90 (P < 0.001), and 120 days. Moreover, there was a significant positive correlation between the VV expansion and the aqueductal CSF stroke between 15 and 60 days. CONCLUSIONS: An initial active phase of rapid ventricular enlargement shows a strong correlation between the expansion of the VV and the increment in the ASV during the first 60 days, followed by a second phase with less ventricular enlargement and heterogeneous behavior in the ASV. Further correlation with complementary data from intracranial pressure and histologic/microstructural brain parenchyma assessments are needed to better understand the ASV variations after 60 days.
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Dates et versions

hal-03599019 , version 1 (06-03-2022)

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Tito Vivas-Buitrago, Armelle Lokossou, Ignacio Jusue-Torres, Gabriel Pinilla-Monsalve, Ari M. Blitz, et al.. Aqueductal Cerebrospinal Fluid Stroke Volume Flow in a Rodent Model of Chronic Communicating Hydrocephalus: Establishing a Homogeneous Study Population for Cerebrospinal Fluid Dynamics Exploration. World Neurosurgery, 2019, 128, pp.E1118-E1125. ⟨10.1016/j.wneu.2019.05.093⟩. ⟨hal-03599019⟩

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